Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

Greg Markby; Kim Summers; Victoria MacRae; Jorge Del-Pozo; Brendan Corcoran

doi:10.1016/j.jcpa.2017.01.009

Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

Greg Markby, Kim Summers, Victoria MacRae, Jorge Del-Pozo, Brendan Corcoran

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Literature review › peer-review

Abstract

Myxomatous mitral valve disease (MMVD) is the single most common acquired heart
disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive re-appraisal of the pathology of MMVD. This paper reviews the gross, histological, ultrastructural, cellular and molecular changes in canine MMVD.

Original language	English
Pages (from-to)	371-383
Journal	Journal of Comparative Pathology
Volume	156
Issue number	4
Early online date	10 Apr 2017
DOIs	https://doi.org/10.1016/j.jcpa.2017.01.009
Publication status	Published - May 2017

Keywords / Materials (for Non-textual outputs)

myxomatous mitral valve disease
dog
pathology
gene expression

Access to Document

10.1016/j.jcpa.2017.01.009

Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular EventsAccepted author manuscript, 1.16 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

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title = "Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events",

abstract = "Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive re-appraisal of the pathology of MMVD. This paper reviews the gross, histological, ultrastructural, cellular and molecular changes in canine MMVD.",

keywords = "myxomatous mitral valve disease, dog, pathology, gene expression",

author = "Greg Markby and Kim Summers and Victoria MacRae and Jorge Del-Pozo and Brendan Corcoran",

year = "2017",

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doi = "10.1016/j.jcpa.2017.01.009",

language = "English",

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pages = "371--383",

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AU - Markby, Greg

AU - Summers, Kim

AU - MacRae, Victoria

AU - Del-Pozo, Jorge

AU - Corcoran, Brendan

PY - 2017/5

Y1 - 2017/5

N2 - Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive re-appraisal of the pathology of MMVD. This paper reviews the gross, histological, ultrastructural, cellular and molecular changes in canine MMVD.

AB - Myxomatous mitral valve disease (MMVD) is the single most common acquired heart disease of the dog, but is also of emerging importance in human medicine, with some features of the disease shared between both species. There has been increased understanding of this disease in recent years, with most research aiming to elucidate the cellular and molecular events of disease pathogenesis. For gross and histological changes, much of our understanding is based on historical studies and there has been no comprehensive re-appraisal of the pathology of MMVD. This paper reviews the gross, histological, ultrastructural, cellular and molecular changes in canine MMVD.

KW - myxomatous mitral valve disease

KW - dog

KW - pathology

KW - gene expression

U2 - 10.1016/j.jcpa.2017.01.009

DO - 10.1016/j.jcpa.2017.01.009

M3 - Literature review

SN - 0021-9975

VL - 156

SP - 371

EP - 383

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

IS - 4

ER -

Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Control of development and reproductive traits

Cite this