Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats

M R Ebrahimkhani, S Kiani, F Oakley, T Kendall, A Shariftabrizi, S M Tavangar, L Moezi, S Payabvash, A Karoon, H Hoseininik, D A Mann, K P Moore, A R Mani, A R Dehpour

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the hypothesis that the opioid system is involved in the development of hepatic fibrosis.
Original languageEnglish
Pages (from-to)1606-16
Number of pages11
JournalGut
Volume55
Issue number11
DOIs
Publication statusPublished - Nov 2006

Keywords

  • Animals
  • Cell Proliferation
  • Cells, Cultured
  • Collagen Type I
  • Liver
  • Liver Cirrhosis, Experimental
  • Male
  • Matrix Metalloproteinase 2
  • Naltrexone
  • Narcotic Antagonists
  • Nitric Oxide
  • Oxidation-Reduction
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Opioid, delta
  • Tissue Inhibitor of Metalloproteinase-1

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