Nanofiber-Coated CF/PEEK Composite: Boosting Osteogenesis for Enhanced Bone Grafting

Dan‐Lei Yang, Louise Stephen, Junaid Qayyum, Dongmin Yang, Colin Farquharson, Norbert Radacsi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

This study presents the fabrication of carbon-fiber-reinforced polyetheretherketone (CF/PEEK) by 3D printing, which is subsequently coated with elastic nanofibers by electrospinning. CF/PEEK is an FDA-approved implantable material possessing excellent mechanical properties similar to those of human cortical bone. As such, it is a prime candidate for replacing conventional metallic implants. However, it is limited by its bioinertness and inferior osteogenic properties. In this study, CF/PEEK is engineered to have improved hydrophilic properties and generated micro/nano-topographical structures on its surface. This is achieved by electrospinning directly onto the 3D-printed CF/PEEK with fibers incorporating hydroxyapatite particles and gelatin. The results show that the micro-/nano-topographical CF/PEEK demonstrates a significant increase in mineralizing potential compared to non-coated implants, where no mineralized matrix is observed. These fiber coating modifications to CF/PEEK are a promising and important step forward in the improvement of in vivo implant-bone osteointegration.

Original languageEnglish
Article number2400286
Pages (from-to)1-6
Number of pages6
JournalMacromolecular materials and engineering
Early online date30 Oct 2024
DOIs
Publication statusE-pub ahead of print - 30 Oct 2024

Keywords / Materials (for Non-textual outputs)

  • CF/PEEK
  • micro/nano-topographical structure
  • biomineralization
  • bone osteointegration
  • bone graft

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