Nanomaterial interactions with biomembranes: bridging the gap between soft matter models and biological context

Marco Werner, Thorsten Auth, Paul Beales, Jean-Baptiste Fleury, Fredrik Hook, Holger Kress, Reid Van Lehn, Marcus Muller, Eugene Petrov, Lev Sarkisov, Jens-Uwe Sommer, Vladimir Baulin

Research output: Contribution to journalArticlepeer-review


Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors’ current understanding of the biological world. This conceptual mismatch makes it challenging to create synthetic nanomaterials
that possess desired functions in biological media. In many biologically relevant applications, nanomaterials must enter the cell interior to perform their functions. An essential transport barrier is the cell-protecting plasma membrane and hence the understanding of its interaction with nanomaterials is a fundamental task in biotechnology. The authors present open questions in the field of nanomaterial interactions with biological membranes, including: how physical mechanisms and molecular
forces acting at the nanoscale restrict or inspire design options; which levels of complexity to include next in computational and experimental models to describe how nanomaterials cross barriers via passive or active processes; and how the biological media and protein corona interfere with nanomaterial functionality. In this perspective article, the authors address these questions with the aim of offering guidelines for the development of next-generation nanomaterials that function in biological media. Published by the AVS.
Original languageEnglish
Article number028501
Issue number2
Early online date3 Apr 2018
Publication statusE-pub ahead of print - 3 Apr 2018


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