Nanoparticle generation by intensified solution crystallization using cold plasma

N. Radacsi, A. E.D.M. van der Heijden, A. I. Stankiewicz, J. H. Ter Horst*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, atmospheric pressure cold plasma (surface dielectric barrier discharge) was used as an alternative energy form to intensify solution crystallization and produce nano-sized organic crystals. Nano-sized particles can have beneficial product properties such as improved internal quality and dissolution rate, compared to conventionally sized crystalline products. In cold plasma intensified crystallization a nebulizer system sprays the solution aerosol into the plasma with the help of a carrier gas. The plasma simultaneously heats and charges the droplets causing fast solvent evaporation and Coulomb-fission to occur, after which nucleation and crystal growth commence within the small, confined volume offered by the small droplets. In this manner, nano-sized crystals of the energetic material RDX and the pharmaceutical niflumic acid were produced.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalChemical Engineering and Processing: Process Intensification
Volume71
DOIs
Publication statusPublished - 1 Sep 2013

Keywords

  • API
  • Cold plasma
  • Crystallization
  • Nanoparticle synthesis
  • Niflumic acid
  • Process intensification
  • RDX

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