Nanoparticle “switch-on” by tetrazine triggering

Kevin Neumann; Sarthak Jain; Jin Geng; Mark Bradley

doi:10.1039/C6CC05118A

Nanoparticle “switch-on” by tetrazine triggering

Kevin Neumann, Sarthak Jain, Jin Geng, Mark Bradley

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.

Original language	English
Pages (from-to)	11223-11226
Journal	Chemical Communications
Volume	52
Issue number	75
Early online date	19 Aug 2016
DOIs	https://doi.org/10.1039/C6CC05118A
Publication status	E-pub ahead of print - 19 Aug 2016

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10.1039/C6CC05118A

Nanoparticle “switch-on” by tetrazine triggeringAccepted author manuscript, 5.07 MBLicence: Creative Commons: Attribution (CC-BY)

http://xlink.rsc.org/?DOI=C6CC05118A

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title = "Nanoparticle “switch-on” by tetrazine triggering",

abstract = "This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.",

author = "Kevin Neumann and Sarthak Jain and Jin Geng and Mark Bradley",

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AB - This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.

U2 - 10.1039/C6CC05118A

DO - 10.1039/C6CC05118A

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JO - Chemical Communications

JF - Chemical Communications

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Nanoparticle “switch-on” by tetrazine triggering

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