Nanoparticle Translocation through Conical Nanopores: A Finite Element Study of Electrokinetic Transport

Georg Rempfer, Sascha Ehrhardt, Christian Holm, Joost de Graaf

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Recent years have seen a surge of interest in nanopores because such structures show a strong potential for characterizing macromolecules, e.g., DNA. Here, the authors theoretically investigate the translocation of a spherical nanoparticle through a conical nanocapillary, by numerically solving the coupled system of electrokinetic continuum equations. Based on their findings, the authors formulate simple guidelines for obtaining the maximum current signal during the translocation event, which should be transferable to other nanopore geometries. In addition, the dependence of the signal strength on particle properties, such as surface charge and size, is evaluated. Finally, the authors identify conditions under which the translocation is prevented by the formation of a strong electroosmotic barrier and show that the particle may even become trapped at the pore orifice, without imposing an external hydrostatic pressure difference.
Original languageEnglish
Article number1600051
JournalMacromolecular Theory and Simulations
Volume26
Issue number1
Early online date26 Sept 2016
DOIs
Publication statusPublished - 2017

Keywords / Materials (for Non-textual outputs)

  • chemistry

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