Projects per year
Abstract
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
Original language | English |
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Journal | Bioorganic and Medicinal Chemistry |
Early online date | 15 Jul 2019 |
DOIs | |
Publication status | E-pub ahead of print - 15 Jul 2019 |
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Development of phloem-mobile xenobiotics with enhanced transport properties
1/06/15 → 30/06/19
Project: Research
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Development of phloem-mobile xenobiotics with enhanced transport properties
Oparka, K.
1/06/15 → 30/06/19
Project: Research