Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Zhiming Cheng, Wagner O Valenca, Gleiston G Dias, Jamie Scott, Nicole D Barth, Fabio De Moliner, Gabriela B P Souza, Richard Mellanby, Eufranio N da Silva Junior, Marc Vendrell Escobar

Research output: Contribution to journalArticlepeer-review

Abstract

Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
Original languageEnglish
JournalBioorganic and Medicinal Chemistry
Early online date15 Jul 2019
DOIs
Publication statusE-pub ahead of print - 15 Jul 2019

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