Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Zhiming Cheng; Wagner O Valenca; Gleiston G Dias; Jamie Scott; Nicole D Barth; Fabio De Moliner; Gabriela B P Souza; Richard Mellanby; Eufranio N da Silva Junior; Marc Vendrell Escobar

doi:10.1016/j.bmc.2019.07.017

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Zhiming Cheng, Wagner O Valenca, Gleiston G Dias, Jamie Scott, Nicole D Barth, Fabio De Moliner, Gabriela B P Souza, Richard Mellanby, Eufranio N da Silva Junior, Marc Vendrell Escobar

Research output: Contribution to journal › Article › peer-review

Abstract

Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.

Original language	English
Journal	Bioorganic and Medicinal Chemistry
Early online date	15 Jul 2019
DOIs	https://doi.org/10.1016/j.bmc.2019.07.017
Publication status	E-pub ahead of print - 15 Jul 2019

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10.1016/j.bmc.2019.07.017

2019-BMC-Cheng accepted manuscript
Author's peer reviewed manuscript as accepted for publication.
Accepted author manuscript, 1.01 MBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

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2 Finished

Dynamic Activatable Fluorophores
Vendrell Escobar, M.
EU government bodies
1/06/18 → 31/05/23
Project: Research
Development of phloem-mobile xenobiotics with enhanced transport properties
Vendrell Escobar, M.
BBSRC
1/06/15 → 30/06/19
Project: Research
Development of phloem-mobile xenobiotics with enhanced transport properties
Oparka, K.
BBSRC
1/06/15 → 30/06/19
Project: Research

Cite this

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title = "Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues",

abstract = "Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.",

author = "Zhiming Cheng and Valenca, {Wagner O} and Dias, {Gleiston G} and Jamie Scott and Barth, {Nicole D} and {De Moliner}, Fabio and Souza, {Gabriela B P} and Richard Mellanby and {da Silva Junior}, {Eufranio N} and {Vendrell Escobar}, Marc",

year = "2019",

month = jul,

day = "15",

doi = "10.1016/j.bmc.2019.07.017",

language = "English",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

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T1 - Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

AU - Cheng, Zhiming

AU - Valenca, Wagner O

AU - Dias, Gleiston G

AU - Scott, Jamie

AU - Barth, Nicole D

AU - De Moliner, Fabio

AU - Souza, Gabriela B P

AU - Mellanby, Richard

AU - da Silva Junior, Eufranio N

AU - Vendrell Escobar, Marc

PY - 2019/7/15

Y1 - 2019/7/15

N2 - Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.

AB - Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.

U2 - 10.1016/j.bmc.2019.07.017

DO - 10.1016/j.bmc.2019.07.017

M3 - Article

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

ER -

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Abstract

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Dynamic Activatable Fluorophores

Development of phloem-mobile xenobiotics with enhanced transport properties

Development of phloem-mobile xenobiotics with enhanced transport properties

Cite this