NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

Margaret C Frame; Gareth J Inman

doi:10.1016/j.devcel.2008.09.016

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

Original language	English
Pages (from-to)	494-6
Number of pages	3
Journal	Developmental Cell
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2008.09.016
Publication status	Published - 2008

Keywords / Materials (for Non-textual outputs)

Animals
Cadherins
Focal Adhesions
Gene Expression
humans
Integrins
Neural Cell Adhesion Molecules
Signal Transduction

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10.1016/j.devcel.2008.09.016

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation
Copyright 2008 Elsevier Inc.
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title = "NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation",

abstract = "New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.",

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journal = "Developmental Cell",

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AU - Frame, Margaret C

AU - Inman, Gareth J

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AB - New work by Lehembre et al. in The EMBO Journal reveals that the cell-adhesion molecule, NCAM, is at the heart of crosstalk between E-cadherin loss and reciprocal focal adhesion assembly during the epithelial to mesenchymal transition (EMT). NCAM upregulation induces the formation of novel signaling complexes that correlate with NCAM-dependent focal adhesion assembly, migration, and cancer cell invasion.

KW - Animals

KW - Cadherins

KW - Focal Adhesions

KW - Gene Expression

KW - humans

KW - Integrins

KW - Neural Cell Adhesion Molecules

KW - Signal Transduction

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DO - 10.1016/j.devcel.2008.09.016

M3 - Article

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SN - 1878-1551

VL - 15

SP - 494

EP - 496

JO - Developmental Cell

JF - Developmental Cell

IS - 4

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NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation

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