NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

N. J. Bradshaw, S. Christie, D. C. Soares, B. C. Carlyle, D. J. Porteous, J. K. Millar

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalNeuroscience Letters
Volume449
Issue number3
DOIs
Publication statusPublished - Jan 2009

Keywords

  • DISC1
  • LIS1
  • NDE1
  • NDEL1
  • Schizophrenia

Fingerprint

Dive into the research topics of 'NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction'. Together they form a unique fingerprint.

Cite this