NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS

Maïwenn Kersaudy-Kerhoas; Antonio Liga; Appan Roychoudhury; Marilena Stamouli; Rhiannon Grant; Damaso Sanchez Carrera; Holger Schulze; Witold Mielczarek; Wilna Oosthuyzen; Juan Quintana-Alcala; Paul Dickinson; Amy H. Buck; Nicholas R. Leslie; Jurgen Haas; Till T. Bachmann; James W. Dear

NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS

Maïwenn Kersaudy-Kerhoas^*, Antonio Liga, Appan Roychoudhury, Marilena Stamouli, Rhiannon Grant, Damaso Sanchez Carrera, Holger Schulze, Witold Mielczarek, Wilna Oosthuyzen, Juan Quintana-Alcala, Paul Dickinson, Amy H. Buck, Nicholas R. Leslie, Jurgen Haas, Till T. Bachmann, James W. Dear

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

Original language	English
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	564-565
Number of pages	2
ISBN (Electronic)	9781733419048
Publication status	Published - 2022
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 - Hybrid, Hangzhou, China Duration: 23 Oct 2022 → 27 Oct 2022

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	23/10/22 → 27/10/22

Keywords / Materials (for Non-textual outputs)

Blood
Drug-Induced Liver Injury
MicroRNA
miR-122

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Cite this

Kersaudy-Kerhoas, M., Liga, A., Roychoudhury, A., Stamouli, M., Grant, R., Carrera, D. S., Schulze, H., Mielczarek, W., Oosthuyzen, W., Quintana-Alcala, J., Dickinson, P., Buck, A. H., Leslie, N. R., Haas, J., Bachmann, T. T., & Dear, J. W. (2022). NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 564-565). Chemical and Biological Microsystems Society. https://www.cbmsociety.org/conference/proceedings_archive.html

@inproceedings{674e368e386542609e7fcccc437d1ea7,

title = "NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS",

abstract = "Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.",

keywords = "Blood, Drug-Induced Liver Injury, MicroRNA, miR-122",

author = "Ma{\"i}wenn Kersaudy-Kerhoas and Antonio Liga and Appan Roychoudhury and Marilena Stamouli and Rhiannon Grant and Carrera, \{Damaso Sanchez\} and Holger Schulze and Witold Mielczarek and Wilna Oosthuyzen and Juan Quintana-Alcala and Paul Dickinson and Buck, \{Amy H.\} and Leslie, \{Nicholas R.\} and Jurgen Haas and Bachmann, \{Till T.\} and Dear, \{James W.\}",

note = "Funding Information: This research was funded by Rosetrees Trust (Ref: M717), and EPSRC grant EP/R00398X/1 Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

year = "2022",

language = "English",

pages = "564--565",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

}

Kersaudy-Kerhoas, M, Liga, A, Roychoudhury, A, Stamouli, M, Grant, R, Carrera, DS, Schulze, H, Mielczarek, W, Oosthuyzen, W, Quintana-Alcala, J, Dickinson, P , Buck, AH, Leslie, NR, Haas, J , Bachmann, TT & Dear, JW 2022, NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 564-565, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022, Hybrid, Hangzhou, China, 23/10/22. <https://www.cbmsociety.org/conference/proceedings_archive.html>

NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS. / Kersaudy-Kerhoas, Maïwenn; Liga, Antonio; Roychoudhury, Appan et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 564-565.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS

AU - Kersaudy-Kerhoas, Maïwenn

AU - Liga, Antonio

AU - Roychoudhury, Appan

AU - Stamouli, Marilena

AU - Grant, Rhiannon

AU - Carrera, Damaso Sanchez

AU - Schulze, Holger

AU - Mielczarek, Witold

AU - Oosthuyzen, Wilna

AU - Quintana-Alcala, Juan

AU - Dickinson, Paul

AU - Buck, Amy H.

AU - Leslie, Nicholas R.

AU - Haas, Jurgen

AU - Bachmann, Till T.

AU - Dear, James W.

N1 - Funding Information: This research was funded by Rosetrees Trust (Ref: M717), and EPSRC grant EP/R00398X/1 Publisher Copyright: © 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

AB - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

KW - Blood

KW - Drug-Induced Liver Injury

KW - MicroRNA

KW - miR-122

UR - https://www.scopus.com/pages/publications/85175696283

M3 - Conference contribution

AN - SCOPUS:85175696283

SP - 564

EP - 565

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

NEAR-PATIENT EXTRACTION AND DETECTION OF MIR-122 MICRORNA BIOMARKER FOR DRUG-INDUCED LIVER INJURY DIAGNOSTICS

Abstract

Conference

Keywords / Materials (for Non-textual outputs)

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