Nedd8 processing enzymes in Schizosaccharomyces pombe

Jean E O'Donoghue, Dawadschargal Bech-Otschir, Ida B Larsen, Mairi Wallace, Rasmus Hartmann-Petersen, Colin Gordon

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators. Like ubiquitin, Nedd8 is produced as a precursor that must first be processed before it becomes active. In Saccharomyces cerevisiae this is carried out exclusively by the enzyme Yuh1.
Original languageEnglish
Pages (from-to)8
JournalBMC biochemistry
Volume14
DOIs
Publication statusPublished - 15 Mar 2013

Keywords / Materials (for Non-textual outputs)

  • Cullin Proteins
  • Escherichia coli
  • Protein Processing, Post-Translational
  • Recombinant Fusion Proteins
  • Schizosaccharomyces
  • Schizosaccharomyces pombe Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases

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