Projects per year
Abstract / Description of output
NLK interacts with Foxp3 in TREG cells and directly phosphorylates Foxp3 on multiple serine residues. This phosphorylation results in stabilization of Foxp3 protein levels by preventing association with the STUB1 E3-ubiquitin protein ligase, resulting in both reduced ubiquitination and proteasome-mediated degradation. Conditional TREG cell NLK-knockout (NLKΔTREG) results in decreased TREG cell-mediated immunosuppression in vivo and NLK-deficient TREG cell animals develop more severe experimental autoimmune encephalomyelitis. Our data suggest a molecular mechanism, in which stimulation of TCR-mediated signaling can induce a TAK1-NLK pathway to sustain Foxp3 transcriptional activity through stabilization of protein levels, thereby maintaining TREG cell suppressive function.
Keywords / Materials (for Non-textual outputs)
- Treg cell
- T cell
FingerprintDive into the research topics of 'Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells'. Together they form a unique fingerprint.
- 3 Finished
Epidermal growth factor receptor antagonists: Effect on regulatory T cells, and use as an adjuvant treatment for infectious disease
McCrae, J. & Gray, D.
5/08/15 → 4/08/18
1/04/15 → 31/03/18
1/03/14 → 28/02/18