Neoadjuvant endocrine therapy in postmenopausal women with HR+/HER2- breast cancer

Carlos Martínez pérez, Arran K Turnbull, Charlene Kay, MIchael Dixon

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Introduction: While endocrine therapy is the standard-of-care adjuvant treatment for hormone receptor-positive (HR+) breast cancers, there is also extensive evidence for the role of pre-operative (or neoadjuvant) endocrine therapy (NET) in HR+ postmenopausal women.
Areas covered: We conducted a thorough review of the published literature, to summarise the evidence to date, including studies of how NET compares to neoadjuvant chemotherapy, which NET agents are preferable, and the optimal duration of NET. We describe the importance of on-treatment assessment of response, the different predictors available (including Ki67, PEPI score and molecular signatures) and the research opportunities the pre-operative setting offers. We also summarise recent combination trials and discuss how the COVID-19 pandemic led to increases in NET use for safe management of cases with deferred surgery and adjuvant treatments.
Expert opinion: NET represents a safe and effective tool for the management of
postmenopausal women with HR+/HER2- breast cancer, enabling disease downstaging and a wider range of surgical options. Aromatase inhibitors are the preferred NET, with evidence suggesting that longer regimens might yield optimal results. However, NET remains currently underutilised in many territories and institutions. Further validation of predictors for treatment response and benefit is needed to help standardise and fully exploit the potential of NET in the clinic.
Original languageEnglish
Pages (from-to)67-86
JournalExpert Review of Anticancer Therapy
Issue number1
Early online date12 Jan 2023
Publication statusE-pub ahead of print - 12 Jan 2023

Keywords / Materials (for Non-textual outputs)

  • Breast cancer
  • ER+
  • HR+
  • HR+/HER2-
  • Pre-operative therapy
  • endocrine therapy
  • neoadjuvant therapy
  • postmenopausal


Dive into the research topics of 'Neoadjuvant endocrine therapy in postmenopausal women with HR+/HER2- breast cancer'. Together they form a unique fingerprint.

Cite this