Projects per year
Abstract / Description of output
Epithelial tubules must have the right length and pattern for proper function. In the nephron, planar cell polarity controls elongation along the proximal-distal axis. As the tubule lengthens, specialized segments (proximal, distal etc.) begin to differentiate along it. Other epithelia need Rho-kinase for planar cell polarity but it is not known whether Rho-kinase is involved in this way in the nephron. We show that Rho-kinase is essential for the morphogenesis of nephrons, specifically for correct cell orientation and volume. We use fluorescent reporter-models and progenitor-specific markers to demonstrate that inhibition of Rho-kinase prevents proper proximal-distal axis formation, causes segments to develop abnormally, and progenitor-cell segregation to fail. Our data demonstrate the importance of Rho-kinase in normal nephron tubulogenesis and patterning.
Original language | English |
---|---|
Pages (from-to) | 1-8 |
Journal | Scientific Reports |
Volume | 3 |
Issue number | 2692 |
DOIs | |
Publication status | Published - 18 Sept 2013 |
Fingerprint
Dive into the research topics of 'Nephrons require Rho-kinase for proximal-distal polarity development'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Reducing mouse no complex genetic exper
Hohenstein, P.
UK central government bodies/local authorities, health and hospital authorities
1/10/12 → 9/07/14
Project: Research
-
Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
1/04/12 → 31/03/17
Project: Research