TY - JOUR
T1 - Networks Underlie Temporal Onset of Dysplasia-Related Epilepsy
T2 - A MELD Study
AU - Multi-Centre Epilepsy Lesion Detection (MELD) Project
AU - Cohen, Nathan T.
AU - You, Xiaozhen
AU - Krishnamurthy, Manu
AU - Sepeta, Leigh N.
AU - Zhang, Anqing
AU - Oluigbo, Chima
AU - Whitehead, Matthew T.
AU - Gholipour, Taha
AU - Baldeweg, Torsten
AU - Wagstyl, Konrad
AU - Adler, Sophie
AU - Gaillard, William D.
AU - Ripart, Mathilde
AU - Whitaker, Kirstie
AU - Napolitano, Antonio
AU - De Palma, Luca
AU - De Benedictis, Alessandro
AU - Foldes, Stephen
AU - Humphreys, Zachary
AU - Zhang, Kai
AU - Hu, Wenhan
AU - Mo, Jiajie
AU - Likeman, Marcus
AU - Davies, Shirin
AU - Güttler, Christopher
AU - Lenge, Matteo
AU - Cohen, Nathan T.
AU - Tang, Yingying
AU - Wang, Shan
AU - Chari, Aswin
AU - Tisdall, Martin
AU - Bargallo, Nuria
AU - Conde-Blanco, Estefanía
AU - Pariente, Jose Carlos
AU - Pascual-Diaz, Saül
AU - Delgado-Martínez, Ignacio
AU - Pérez-Enríquez, Carmen
AU - Lagorio, Ilaria
AU - Abela, Eugenio
AU - Mullatti, Nandini
AU - O'Muircheartaigh, Jonathan
AU - Vecchiato, Katy
AU - Liu, Yawu
AU - Caligiuri, Maria Eugenia
AU - Sinclair, Ben
AU - Vivash, Lucy
AU - Willard, Anna
AU - Kandasamy, Jothy
AU - McLellan, Ailsa
AU - Sokol, Drahoslav
AU - Semmelroch, Mira
AU - Kloster, Ane G.
AU - Opheim, Giske
AU - Ribeiro, Letícia
AU - Yasuda, Clarissa
AU - Rossi-Espagnet, Camilla
AU - Hamandi, Khalid
AU - Tietze, Anna
AU - Barba, Carmen
AU - Guerrini, Renzo
AU - Gaillard, William Davis
AU - You, Xiaozhen
AU - Wang, Irene
AU - González-Ortiz, Sofía
AU - Severino, Mariasavina
AU - Striano, Pasquale
AU - Tortora, Domenico
AU - Kälviäinen, Reetta
AU - Gambardella, Antonio
AU - Labate, Angelo
AU - Desmond, Patricia
AU - Lui, Elaine
AU - O'Brien, Terence
AU - Shetty, Jay
AU - Jackson, Graeme
AU - Duncan, John S.
AU - Winston, Gavin
AU - Pinborg, Lars H.
AU - Cendes, Fernando
AU - Cross, J. Helen
AU - Baldeweg, Torsten
AU - Adler, Sophie
AU - Wagstyl, Konrad
N1 - Funding Information:
MELD is supported by the Rosetrees Trust (A2665). N.T.C. is supported by the Pediatric Epilepsy Research Foundation/Child Neurology Foundation Shields Research Grant and the Children's National Research Institute Chief Research Officer Award. This work was also supported by the DC-IDDRC NICHD NIH U54 HD090257. This publication was supported by Award Number UL1TR001876 from the NIH National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.
Funding Information:
MELD is supported by the Rosetrees Trust (A2665). N.T.C. is supported by the Pediatric Epilepsy Research Foundation/Child Neurology Foundation Shields Research Grant and the Children's National Research Institute Chief Research Officer Award. This work was also supported by the DC‐IDDRC NICHD NIH U54 HD090257. This publication was supported by Award Number UL1TR001876 from the NIH National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.
Publisher Copyright:
© 2022 American Neurological Association.
PY - 2022/9
Y1 - 2022/9
N2 - Objective: The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD. Methods: International (20 center), retrospective cohort from the Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) with radiologic or histopathologic FCD after surgery. Images processed using the MELD protocol, masked with 3D regions-of-interest (ROI), and co-registered to fsaverage_sym (symmetric template). FCDs were then co-localized to 1 of 7 distributed functional cortical networks. Negative binomial regression evaluated effect of FCD size, network, histology, and sulcal depth on age of epilepsy onset. From this model, predictive age of epilepsy onset was calculated for each network. Results: Three hundred eighty-eight patients had median age seizure onset 5 years (interquartile range [IQR] = 3–11 years), median age at pre-operative scan 18 years (IQR = 11–28 years). FCDs co-localized to the following networks: limbic (90), default mode (87), somatomotor (65), front parietal control (52), ventral attention (32), dorsal attention (31), and visual (31). Larger lesions were associated with younger age of onset (p = 0.01); age of epilepsy onset was associated with dominant network (p = 0.04) but not sulcal depth or histology. Sensorimotor networks had youngest onset; the limbic network had oldest age of onset (p values <0.05). Interpretation: FCD co-localization to distributed functional cortical networks is associated with age of epilepsy onset: sensory neural networks (somatomotor and visual) with earlier onset, and limbic latest onset. These variations may reflect developmental differences in synaptic/white matter maturation or network activation and may provide a biological basis for age-dependent epilepsy onset expression. ANN NEUROL 2022;92:503–511.
AB - Objective: The purpose of this study was to evaluate if focal cortical dysplasia (FCD) co-localization to cortical functional networks is associated with the temporal distribution of epilepsy onset in FCD. Methods: International (20 center), retrospective cohort from the Multi-Centre Epilepsy Lesion Detection (MELD) project. Patients included if >3 years old, had 3D pre-operative T1 magnetic resonance imaging (MRI; 1.5 or 3 T) with radiologic or histopathologic FCD after surgery. Images processed using the MELD protocol, masked with 3D regions-of-interest (ROI), and co-registered to fsaverage_sym (symmetric template). FCDs were then co-localized to 1 of 7 distributed functional cortical networks. Negative binomial regression evaluated effect of FCD size, network, histology, and sulcal depth on age of epilepsy onset. From this model, predictive age of epilepsy onset was calculated for each network. Results: Three hundred eighty-eight patients had median age seizure onset 5 years (interquartile range [IQR] = 3–11 years), median age at pre-operative scan 18 years (IQR = 11–28 years). FCDs co-localized to the following networks: limbic (90), default mode (87), somatomotor (65), front parietal control (52), ventral attention (32), dorsal attention (31), and visual (31). Larger lesions were associated with younger age of onset (p = 0.01); age of epilepsy onset was associated with dominant network (p = 0.04) but not sulcal depth or histology. Sensorimotor networks had youngest onset; the limbic network had oldest age of onset (p values <0.05). Interpretation: FCD co-localization to distributed functional cortical networks is associated with age of epilepsy onset: sensory neural networks (somatomotor and visual) with earlier onset, and limbic latest onset. These variations may reflect developmental differences in synaptic/white matter maturation or network activation and may provide a biological basis for age-dependent epilepsy onset expression. ANN NEUROL 2022;92:503–511.
UR - http://www.scopus.com/inward/record.url?scp=85133834660&partnerID=8YFLogxK
U2 - 10.1002/ana.26442
DO - 10.1002/ana.26442
M3 - Article
C2 - 35726354
AN - SCOPUS:85133834660
SN - 0364-5134
VL - 92
SP - 503
EP - 511
JO - Annals of Neurology
JF - Annals of Neurology
IS - 3
ER -