TY - JOUR
T1 - Neue ansätze zur analyse von axon-oligodendrozyten kommunikation in vivo
AU - Czopka, Tim
AU - Auer, Franziska
N1 - Funding Information:
Technical University of Munich, Institute of Neuronal Cell Biology, Munich Cluster of Systems Neurology (SyNergy), Bieder-steiner St. 29, 80802 München, Germany Phone: 089-4140 3377 Fax: 089-4140 3258 Mail: [email protected] Web: http://www.neuroscience.med.tum. de; https://www.czopka-lab.de Tim Czopka (*1980) studied biology at the Ruhr University Bochum, where he also obtained his PhD in neurosciences in 2009 (summa cum laude). After a postdoctoral stay at the University of Edinburgh (2010-2014), he moved to the Technical University of Munich where he is currently leading a junior research group. His work is currently funded by the Emmy-Noether programme of the DFG, the Munich Cluster of Systems Neurology (SyNergy), and an ERC Starting Grant (ERC-StG).
Funding Information:
Technical University of Munich, Institute of Neuronal Cell Biology, Biedersteiner Str. 29, 80802 München, Germany Mail: [email protected] Franziska Auer (*1991) studied Pharmaceutical Sciences at the Ludwig-Maximilian Universität (LMU) Munich, and is currently PhD student in the group of Tim Czopka. She is part of the LMU Graduate School of Systemic Neurosciences (GSN) and holds a scholarship of the Gertrud-Reemtsma Foundation of the Max Planck Society.
Publisher Copyright:
© 2017 Spektrum Akademischer Verlag. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - A major challenge for understanding our nervous system is to elucidate how its constituting cells coordinate each other to form and maintain a functional organ. The interaction between neurons and oligodendrocytes represents a unique cellular entity. Oligodendrocytes myelinate axons by tightly ensheathing them. Myelination regulates speed of signal transduction, thus communication between neurons, and supports long-term axonal health. Despite their importance, we still have large gaps in our understanding of the mechanisms underlying myelinated axon formation, remodelling and repair. Zebrafish represent an increasingly popular model organism, particularly due to their suitability for live cell imaging and genetic manipulation. Here, we provide an overview about this research area, describe how zebrafish have helped understanding mechanisms of myelination, and discuss how zebrafish may help addressing open questions related to the control of axon-oligodendrocyte interactions.
AB - A major challenge for understanding our nervous system is to elucidate how its constituting cells coordinate each other to form and maintain a functional organ. The interaction between neurons and oligodendrocytes represents a unique cellular entity. Oligodendrocytes myelinate axons by tightly ensheathing them. Myelination regulates speed of signal transduction, thus communication between neurons, and supports long-term axonal health. Despite their importance, we still have large gaps in our understanding of the mechanisms underlying myelinated axon formation, remodelling and repair. Zebrafish represent an increasingly popular model organism, particularly due to their suitability for live cell imaging and genetic manipulation. Here, we provide an overview about this research area, describe how zebrafish have helped understanding mechanisms of myelination, and discuss how zebrafish may help addressing open questions related to the control of axon-oligodendrocyte interactions.
KW - Axon
KW - In vivo imaging
KW - Myelin
KW - Oligodendrocyte
KW - Zebrafish
UR - https://www.scopus.com/pages/publications/85050474730
U2 - 10.1515/nf-2017-A010
DO - 10.1515/nf-2017-A010
M3 - Review article
AN - SCOPUS:85050474730
SN - 0947-0875
VL - 23
SP - 231-238 and A175-A181
JO - Neuroforum
JF - Neuroforum
IS - 4
ER -