Neurocognitive phenomics: examining the genetic basis of cognitive abilities

G. Donohoe*, I. J. Deary, D. C. Glahn, A. K. Malhotra, K. E. Burdick

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Cognitive deficits are core to the disability associated with many psychiatric disorders. Both variation in cognition and psychiatric risk show substantial heritability, with overlapping genetic variants contributing to both. Unsurprisingly, therefore, these fields have been mutually beneficial : just as cognitive studies of psychiatric risk variants may identify genes involved in cognition, so too can genome-wide studies based on cognitive phenotypes lead to genes relevant to psychiatric aetiology. The purpose of this review is to consider the main issues involved in the phenotypic characterization of cognition, and to describe the challenges associated with the transition to genome-wide approaches. We conclude by describing the approaches currently being taken by the international consortia involving many investigators in the field internationally (e. g. Cognitive Genomics Consortium; COGENT) to overcome these challenges.

Original languageEnglish
Pages (from-to)2027-2036
Number of pages10
JournalPsychological Medicine
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Cognition
  • endophenotype
  • genetics
  • GWAS
  • schizophrenia
  • HUMAN INTELLIGENCE DIFFERENCES
  • MONOZYGOTIC TWINS DISCORDANT
  • BIPOLAR AFFECTIVE-DISORDER
  • GENOME-WIDE ASSOCIATION
  • INDIVIDUAL-DIFFERENCES
  • NEUROPSYCHOLOGICAL ENDOPHENOTYPES
  • INTERMEDIATE PHENOTYPES
  • PSYCHIATRIC-DISORDERS
  • TEST BATTERIES
  • SCHIZOPHRENIA

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