Neurocysticercosis Infection and Disease – A Review

Lucy Gripper, Susan Welburn

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract
Neurocysticercosis (NCC) is the most common parasitic disease of the human central
nervous system (CNS), a pleomorphic disease with a diverse array of clinical manifestations.
The infection is pleomorphic and dependent on a complex range of interconnecting factors,
including number and size of the cysticerci, their stage of development and localisation
within the brain with resulting difficulties in accurate diagnosis and staging of the disease.
This review examines the factors that contribute to the accurate assessment of NCC
distribution and transmission that are critical to achieving robust disease burden calculations.
Control and prevention of T. solium transmission should be a key priority in global health as
intervention can reduce the substantial healthcare and economic burdens inflicted by both
NCC and taeniasis. Surveillance systems need to be better established, including
implementing obligatory notification of cases. In the absence of reliable estimates of its
global burden, NCC will remain - along with other endemic zoonoses, of low priority in the
eyes of funding agencies– a truly neglected disease.

Abstract
Neurocysticercosis (NCC) is the most common parasitic disease of the human central
nervous system (CNS), a pleomorphic disease with a diverse array of clinical manifestations.
The infection is pleomorphic and dependent on a complex range of interconnecting factors,
including number and size of the cysticerci, their stage of development and localisation
within the brain with resulting difficulties in accurate diagnosis and staging of the disease.
This review examines the factors that contribute to the accurate assessment of NCC
distribution and transmission that are critical to achieving robust disease burden calculations.
Control and prevention of T. solium transmission should be a key priority in global health as
intervention can reduce the substantial healthcare and economic burdens inflicted by both
NCC and taeniasis. Surveillance systems need to be better established, including
implementing obligatory notification of cases. In the absence of reliable estimates of its
global burden, NCC will remain - along with other endemic zoonoses, of low priority in the
eyes of funding agencies– a truly neglected disease.
Original languageEnglish
JournalActa Tropica
Early online date20 Nov 2016
DOIs
Publication statusPublished - Feb 2017

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