Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

M. Bastide*, T. Ouk, F. Plaisier, O. Petrault, S. Stolc, R. Bordet

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential. target in neuroprotection concept. (c) 2007 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)S36-S39
Number of pages4
JournalPsychoneuroendocrinology
Volume32
DOIs
Publication statusPublished - Aug 2007
EventLille Summer School in Neuroscience - Lille, France
Duration: 2 Sept 20067 Sept 2006

Keywords / Materials (for Non-textual outputs)

  • cerebral ischemia
  • cerebral vessel
  • neurological deficit
  • potassium channel
  • pharmacological neuroprotection
  • pharmacological vasculoprotection
  • ENDOTHELIAL DYSFUNCTION
  • ARTERY OCCLUSION
  • SMOOTH-MUSCLE
  • REPERFUSION
  • IMPAIRMENT
  • STOBADINE
  • ISCHEMIA/REPERFUSION
  • LIPOPOLYSACCHARIDE
  • TOLERANCE
  • RECOVERY

Fingerprint

Dive into the research topics of 'Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target'. Together they form a unique fingerprint.

Cite this