Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

M. Bastide; T. Ouk; F. Plaisier; O. Petrault; S. Stolc; R. Bordet

doi:10.1016/j.psyneuen.2007.03.015

Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

M. Bastide^*, T. Ouk, F. Plaisier, O. Petrault, S. Stolc, R. Bordet

^*Corresponding author for this work

Deanery of Biomedical Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential. target in neuroprotection concept. (c) 2007 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	S36-S39
Number of pages	4
Journal	Psychoneuroendocrinology
Volume	32
DOIs	https://doi.org/10.1016/j.psyneuen.2007.03.015
Publication status	Published - Aug 2007
Event	Lille Summer School in Neuroscience - Lille, France Duration: 2 Sept 2006 → 7 Sept 2006

Keywords / Materials (for Non-textual outputs)

cerebral ischemia
cerebral vessel
neurological deficit
potassium channel
pharmacological neuroprotection
pharmacological vasculoprotection
ENDOTHELIAL DYSFUNCTION
ARTERY OCCLUSION
SMOOTH-MUSCLE
REPERFUSION
IMPAIRMENT
STOBADINE
ISCHEMIA/REPERFUSION
LIPOPOLYSACCHARIDE
TOLERANCE
RECOVERY

Access to Document

10.1016/j.psyneuen.2007.03.015

Cite this

@article{b37a207cb013480cb14cbd678df9b16e,

title = "Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target",

abstract = "Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential. target in neuroprotection concept. (c) 2007 Elsevier Ltd. All rights reserved.",

keywords = "cerebral ischemia, cerebral vessel, neurological deficit, potassium channel, pharmacological neuroprotection, pharmacological vasculoprotection, ENDOTHELIAL DYSFUNCTION, ARTERY OCCLUSION, SMOOTH-MUSCLE, REPERFUSION, IMPAIRMENT, STOBADINE, ISCHEMIA/REPERFUSION, LIPOPOLYSACCHARIDE, TOLERANCE, RECOVERY",

author = "M. Bastide and T. Ouk and F. Plaisier and O. Petrault and S. Stolc and R. Bordet",

year = "2007",

month = aug,

doi = "10.1016/j.psyneuen.2007.03.015",

language = "English",

volume = "32",

pages = "S36--S39",

journal = "Psychoneuroendocrinology",

issn = "0306-4530",

publisher = "Elsevier",

note = "Lille Summer School in Neuroscience ; Conference date: 02-09-2006 Through 07-09-2006",

}

TY - JOUR

T1 - Neurogliovascular unit after cerebral ischemia

T2 - Lille Summer School in Neuroscience

AU - Bastide, M.

AU - Ouk, T.

AU - Plaisier, F.

AU - Petrault, O.

AU - Stolc, S.

AU - Bordet, R.

PY - 2007/8

Y1 - 2007/8

N2 - Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential. target in neuroprotection concept. (c) 2007 Elsevier Ltd. All rights reserved.

AB - Ischemic stroke induces drastic alterations of the functions of the neurogliovascular unit with dramatic consequences on the well-being of the patients in terms of cognitive and motor handicap. Nowadays, only very few therapeutics are available as a treatment of ischemic stroke. Ischemia is a multifactorial pathology involving different cerebral cellular components such as neurons, astrocytes and vessels working as a functional unit. Recent experimental strategy investigation involving different agents with antioxidant properties (dt-BC, stobadine) or pleiotropic effects (lipopolysaccharide, LPS) has been developed to evaluate whether the vascular wall could be considered as a potential. target in neuroprotection concept. (c) 2007 Elsevier Ltd. All rights reserved.

KW - cerebral ischemia

KW - cerebral vessel

KW - neurological deficit

KW - potassium channel

KW - pharmacological neuroprotection

KW - pharmacological vasculoprotection

KW - ENDOTHELIAL DYSFUNCTION

KW - ARTERY OCCLUSION

KW - SMOOTH-MUSCLE

KW - REPERFUSION

KW - IMPAIRMENT

KW - STOBADINE

KW - ISCHEMIA/REPERFUSION

KW - LIPOPOLYSACCHARIDE

KW - TOLERANCE

KW - RECOVERY

U2 - 10.1016/j.psyneuen.2007.03.015

DO - 10.1016/j.psyneuen.2007.03.015

M3 - Literature review

SN - 0306-4530

VL - 32

SP - S36-S39

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

Y2 - 2 September 2006 through 7 September 2006

ER -

Neurogliovascular unit after cerebral ischemia: Is the vascular wall a pharmacological target

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Cite this