Neuroimaging standards for research into small vessel disease-advances since 2013

Marco Duering, Geert Jan Biessels, Amy Brodtmann, Christopher Chen, Charlotte Cordonnier, Frank-Erik de Leeuw, Stéphanie Debette, Richard Frayne, Eric Jouvent, Natalia S Rost, Annemieke Ter Telgte, Rustam Al-Shahi Salman, Walter H Backes, Hee-Joon Bae, Rosalind Brown, Hugues Chabriat, Alberto De Luca, Charles deCarli, Anna Dewenter, Fergus N DoubalMichael Ewers, Thalia S Field, Aravind Ganesh, Steven Greenberg, Karl G Helmer, Saima Hilal, Angela C C Jochems, Hanna Jokinen, Hugo Kuijf, Bonnie Y K Lam, Jessica Lebenberg, Bradley J MacIntosh, Pauline Maillard, Vincent C T Mok, Leonardo Pantoni, Salvatore Rudilosso, Claudia L Satizabal, Markus D Schirmer, Reinhold Schmidt, Colin Smith, Julie Staals, Michael J Thrippleton, Susanne J van Veluw, Prashanthi Vemuri, Yilong Wang, David Werring, Marialuisa Zedde, Rufus O Akinyemi, Oscar H Del Brutto, Hugh S Markus, Yi-Cheng Zhu, Eric E Smith, Martin Dichgans, Joanna M Wardlaw

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Cerebral small vessel disease (SVD) is common during ageing and can present as stroke, cognitive decline, neurobehavioural symptoms, or functional impairment. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive and other symptoms and affect activities of daily living. Standards for Reporting Vascular Changes on Neuroimaging 1 (STRIVE-1) categorised and standardised the diverse features of SVD that are visible on structural MRI. Since then, new information on these established SVD markers and novel MRI sequences and imaging features have emerged. As the effect of combined SVD imaging features becomes clearer, a key role for quantitative imaging biomarkers to determine sub-visible tissue damage, subtle abnormalities visible at high-field strength MRI, and lesion-symptom patterns, is also apparent. Together with rapidly emerging machine learning methods, these metrics can more comprehensively capture the effect of SVD on the brain than the structural MRI features alone and serve as intermediary outcomes in clinical trials and future routine practice. Using a similar approach to that adopted in STRIVE-1, we updated the guidance on neuroimaging of vascular changes in studies of ageing and neurodegeneration to create STRIVE-2.

Original languageEnglish
JournalLancet Neurology
Early online date23 May 2023
DOIs
Publication statusE-pub ahead of print - 23 May 2023

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