TY - JOUR
T1 - Neuroimmunology of the female brain across the lifespan: plasticity to psychopathology
AU - Barrientos, Ruth M.
AU - Brunton, Paula
AU - Lenz, Katy M.
AU - Pyter, Leah
AU - Spencer, Sarah J.
PY - 2019/3/11
Y1 - 2019/3/11
N2 - The female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in normal individuals; how it adapts to pregnancy and postpartum; how it responds to illness and disease, particularly cancer; and, finally, how it is shaped by old age. Throughout, we will highlight female vulnerability to and resilience against disease and dysfunction in the face of environmental challenges.
AB - The female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in normal individuals; how it adapts to pregnancy and postpartum; how it responds to illness and disease, particularly cancer; and, finally, how it is shaped by old age. Throughout, we will highlight female vulnerability to and resilience against disease and dysfunction in the face of environmental challenges.
U2 - 10.1016/j.bbi.2019.03.010
DO - 10.1016/j.bbi.2019.03.010
M3 - Review article
SN - 0889-1591
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
ER -