Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Sarah Harris; Simon Cox; Steven Bell; Riccardo Marioni; Bram P Prins; Alison Pattie; Janie Corley; Susana Muñoz Maniega; Maria Valdes Hernandez; Zoe Morrison; Sally L. John; Paola G Bronson; Elliot M Tucker-Drob; John Starr; Mark Bastin; Joanna Wardlaw; Adam S Butterworth; Ian Deary

doi:10.1038/s41467-019-14161-7

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Sarah Harris, Simon Cox, Steven Bell, Riccardo Marioni, Bram P Prins, Alison Pattie, Janie Corley, Susana Muñoz Maniega, Maria Valdes Hernandez, Zoe Morrison, Sally L. John, Paola G Bronson, Elliot M Tucker-Drob, John Starr, Mark Bastin, Joanna Wardlaw, Adam S Butterworth, Ian Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

Original language	English
Article number	800
Journal	Nature Communications
Volume	11
DOIs	https://doi.org/10.1038/s41467-019-14161-7
Publication status	Published - 10 Feb 2020

Access to Document

10.1038/s41467-019-14161-7Licence: Creative Commons: Attribution (CC-BY)

HarrisEtalNC2019Neurology-BasedrelatedProteinBiomarkersFinal published version, 1.69 MBLicence: Creative Commons: Attribution (CC-BY)

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J. (Principal Investigator), Bastin, M. (Co-investigator) & Deary, I. (Co-investigator)
MRC
1/05/15 → 30/04/19
Project: Research
RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Wardlaw, J. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
8/06/11 → 7/03/15
Project: Research

Sarah Harris
- School of Philosophy, Psychology and Language Sciences - Senior Research Fellow
- Edinburgh Neuroscience
Person: Academic: Research Active

Cite this

Harris, S., Cox, S., Bell, S., Marioni, R., Prins, B. P., Pattie, A., Corley, J., Muñoz Maniega, S., Valdes Hernandez, M., Morrison, Z., John, S. L., Bronson, P. G., Tucker-Drob, E. M., Starr, J., Bastin, M., Wardlaw, J., Butterworth, A. S., & Deary, I. (2020). Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age. Nature Communications, 11, Article 800. https://doi.org/10.1038/s41467-019-14161-7

@article{f749cbb57cb947efa01e50666b764b9e,

title = "Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age",

abstract = "Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink{\textregistered} Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.",

author = "Sarah Harris and Simon Cox and Steven Bell and Riccardo Marioni and Prins, {Bram P} and Alison Pattie and Janie Corley and {Mu{\~n}oz Maniega}, Susana and {Valdes Hernandez}, Maria and Zoe Morrison and John, {Sally L.} and Bronson, {Paola G} and Tucker-Drob, {Elliot M} and John Starr and Mark Bastin and Joanna Wardlaw and Butterworth, {Adam S} and Ian Deary",

year = "2020",

month = feb,

day = "10",

doi = "10.1038/s41467-019-14161-7",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Harris, S , Cox, S, Bell, S, Marioni, R, Prins, BP, Pattie, A, Corley, J , Muñoz Maniega, S , Valdes Hernandez, M, Morrison, Z, John, SL, Bronson, PG, Tucker-Drob, EM, Starr, J, Bastin, M , Wardlaw, J, Butterworth, AS & Deary, I 2020, 'Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age', Nature Communications, vol. 11, 800. https://doi.org/10.1038/s41467-019-14161-7

TY - JOUR

T1 - Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

AU - Harris, Sarah

AU - Cox, Simon

AU - Bell, Steven

AU - Marioni, Riccardo

AU - Prins, Bram P

AU - Pattie, Alison

AU - Corley, Janie

AU - Muñoz Maniega, Susana

AU - Valdes Hernandez, Maria

AU - Morrison, Zoe

AU - John, Sally L.

AU - Bronson, Paola G

AU - Tucker-Drob, Elliot M

AU - Starr, John

AU - Bastin, Mark

AU - Wardlaw, Joanna

AU - Butterworth, Adam S

AU - Deary, Ian

PY - 2020/2/10

Y1 - 2020/2/10

N2 - Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

AB - Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.

U2 - 10.1038/s41467-019-14161-7

DO - 10.1038/s41467-019-14161-7

M3 - Article

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

M1 - 800

ER -

Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Abstract

Access to Document

Fingerprint

Projects

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Profiles

Sarah Harris

Cite this