TY - JOUR
T1 - Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
AU - Harris, Sarah
AU - Cox, Simon
AU - Bell, Steven
AU - Marioni, Riccardo
AU - Prins, Bram P
AU - Pattie, Alison
AU - Corley, Janie
AU - Muñoz Maniega, Susana
AU - Valdes Hernandez, Maria
AU - Morrison, Zoe
AU - John, Sally L.
AU - Bronson, Paola G
AU - Tucker-Drob, Elliot M
AU - Starr, John
AU - Bastin, Mark
AU - Wardlaw, Joanna
AU - Butterworth, Adam S
AU - Deary, Ian
PY - 2020/2/10
Y1 - 2020/2/10
N2 - Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
AB - Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink® Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4,451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (β between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.
U2 - 10.1038/s41467-019-14161-7
DO - 10.1038/s41467-019-14161-7
M3 - Article
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
M1 - 800
ER -