TY - JOUR
T1 - Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching
AU - Linneweber, Gerit A
AU - Jacobson, Jake
AU - Busch, Karl Emanuel
AU - Hudry, Bruno
AU - Christov, Christo P
AU - Dormann, Dirk
AU - Yuan, Michaela
AU - Otani, Tomoki
AU - Knust, Elisabeth
AU - de Bono, Mario
AU - Miguel-Aliaga, Irene
N1 - RCUK funding
PY - 2014/1/16
Y1 - 2014/1/16
N2 - During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
AB - During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives—rather than responds to—metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.
U2 - 10.1016/j.cell.2013.12.008
DO - 10.1016/j.cell.2013.12.008
M3 - Article
C2 - 24439370
SN - 0092-8674
VL - 156
SP - 69
EP - 83
JO - Cell
JF - Cell
IS - 1-2
ER -