Neuroticism and polymorphisms in the serotonin transporter gene

I J Deary, S Battersby, Martha Whiteman, J M Connor, F G R Fowkes, A Harmar

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background. There is evidence for an association between two different polymorphisms of the human serotonin transporter gene (5-HTT) and the personality trait of neuroticism and affective disorder.

Methods. We studied the association between neuroticism and polymorphisms in the 5HTT-linked promoter region and in a variable number tandem repeat region (VNTR) of the 5-HTT gene in 204 people aged over 60 derived from a random sample of men and women in the general population. Approximately half of the subjects were in the top 20 % of neuroticism scorers and half in the bottom 20 %.

Results. There were no significant differences in allelic or genotypic frequencies between the high and low neuroticism scorers. There was highly significant linkage disequilibrium between the two 5-HTT gene polymorphisms, and haplotype analysis showed no association between neuroticism level and haplotype.

Conclusions. Reports of an association between two 5-HTT gene polymorphisms and the personality trait of neuroticism are not supported by these results.

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalPsychological Medicine
Volume29
Issue number3
Publication statusPublished - May 1999

Keywords / Materials (for Non-textual outputs)

  • BIPOLAR AFFECTIVE-DISORDER
  • PERSONALITY-TRAITS
  • REGULATORY REGION
  • MAJOR DEPRESSION
  • ASSOCIATION
  • MODEL
  • SUSCEPTIBILITY
  • TEMPERAMENT
  • DIMENSIONS
  • POPULATION

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