TY - JOUR
T1 - Neurotoxic phospholipase A2
T2 - A proposed cause of equine grass sickness and other animal dysautonomias (multiple system neuropathies)
AU - McGorum, Bruce
AU - Pirie, R Scott
AU - Bano, Luca
AU - Davey, Tracey
AU - Harris, John
AU - Montecucco, Cesare
PY - 2025/1
Y1 - 2025/1
N2 - Recent studies indicate that a neurotoxic phospholipase A 2 (PLA 2 ;E.C. 3.1.1.4) is a likely cause of equine grass sickness (EGS), 1,2 ahitherto enigmatic acute multiple system neuropathy that kills approximately 1% of horses grazing in high-risk premises. 3,4 It islikely that this neurotoxin also causes the apparently identicalanimal dysautonomias that occur in cats, dogs, hares, rabbits,llamas, alpacas and, possibly, sheep. 5–11 The unidentified neuro-toxic PLA 2 (nPLA 2 ) could be an ingested microbial or plant PLA 2 , ora PLA 2 produced in vivo by gastrointestinal (GI) microbes. Here we summarise details of our current understanding of the aetiopatho-genesis of EGS
AB - Recent studies indicate that a neurotoxic phospholipase A 2 (PLA 2 ;E.C. 3.1.1.4) is a likely cause of equine grass sickness (EGS), 1,2 ahitherto enigmatic acute multiple system neuropathy that kills approximately 1% of horses grazing in high-risk premises. 3,4 It islikely that this neurotoxin also causes the apparently identicalanimal dysautonomias that occur in cats, dogs, hares, rabbits,llamas, alpacas and, possibly, sheep. 5–11 The unidentified neuro-toxic PLA 2 (nPLA 2 ) could be an ingested microbial or plant PLA 2 , ora PLA 2 produced in vivo by gastrointestinal (GI) microbes. Here we summarise details of our current understanding of the aetiopatho-genesis of EGS
U2 - 10.1111/evj.14442
DO - 10.1111/evj.14442
M3 - Editorial
C2 - 39630613
SN - 0425-1644
VL - 57
SP - 11
EP - 18
JO - Equine Veterinary Journal
JF - Equine Veterinary Journal
IS - 1
ER -