Neurotransmitters and peptides: whispered secrets and public announcements

G. Leng, M. Ludwig

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

The magnocellular oxytocin and vasopressin neurones of the hypothalamus are now understood in exceptional detail. Extensive quantitative details from many independent sources are available describing the electrical activity of the neurones in diverse circumstances, the subcellular localization of vesicles, and rates of hormone secretion from nerve endings into the blood and from dendrites into the brain. These data enable the relationship of electrical (spike) activity to vesicle exocytosis to be inferred with some precision. Such calculations lead to the conclusion that exocytosis of peptide-containing vesicles is a relatively rare event even in this vesicle-dense system. At any given release site in the neurohypophysis, it seems that several hundred spikes are needed on average to release a single vesicle. Release from compartments within the brain seems also to be very rare, making it implausible that peptides can act in a temporally precise, anatomically specific manner. However, very large amounts of peptide are released by these infrequent events, consistent with their likely role as neurohormonal messengers.
Original languageEnglish
Pages (from-to)5625-5632
Number of pages8
JournalThe Journal of Physiology
Issue number23
Publication statusPublished - Dec 2008


Dive into the research topics of 'Neurotransmitters and peptides: whispered secrets and public announcements'. Together they form a unique fingerprint.

Cite this