Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia

Brunella Cristofaro, Oliver A Stone, Andrea Caporali, David Dawbarn, Nicholas Ieronimakis, Morayma Reyes, Paolo Madeddu, David O Bates, Costanza Emanueli

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

To investigate the novel hypothesis that neurotrophin-3 (NT-3), an established neurotrophic factor that participates in embryonic heart development, promotes blood vessel growth.
Original languageEnglish
Pages (from-to)1143-50
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume30
Issue number6
DOIs
Publication statusPublished - Jun 2010

Keywords / Materials (for Non-textual outputs)

  • Angiogenic Proteins
  • Animals
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Cells, Cultured
  • Disease Models, Animal
  • Endothelial Cells
  • Genetic Therapy
  • Hindlimb
  • Humans
  • Ischemia
  • Male
  • Mesentery
  • Mice
  • Muscle, Skeletal
  • Neovascularization, Physiologic
  • Nerve Growth Factors
  • Neurotrophin 3
  • Nitric Oxide Synthase Type III
  • Phosphatidylinositol 3-Kinases
  • Phosphorylation
  • Proto-Oncogene Proteins c-akt
  • RNA, Messenger
  • Rats
  • Rats, Wistar
  • Receptor, trkC
  • Recombinant Proteins
  • Signal Transduction
  • Time Factors
  • Transfection

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