New discoveries in the transmission biology of sleeping sickness parasites: applying the basics

Paula MacGregor, Keith R Matthews

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The sleeping sickness parasite, Trypanosoma brucei, must differentiate in response to the changing environments that it encounters during its complex life cycle. One developmental form, the bloodstream stumpy stage, plays an important role in infection dynamics and transmission of the parasite. Recent advances have shed light on the molecular mechanisms by which these stumpy forms differentiate as they are transmitted from the mammalian host to the insect vector of sleeping sickness, tsetse flies. These molecular advances now provide improved experimental tools for the study of stumpy formation and function within the mammalian bloodstream. They also offer new routes to therapy via high-throughput screens for agents that accelerate parasite development. Here, we shall discuss the recent advances that have been made and the prospects for future research now available.
Original languageEnglish
Pages (from-to)865-71
Number of pages7
JournalJournal of Molecular Medicine
Volume88
Issue number9
DOIs
Publication statusPublished - 2010

Fingerprint

Dive into the research topics of 'New discoveries in the transmission biology of sleeping sickness parasites: applying the basics'. Together they form a unique fingerprint.

Cite this