New horizons for stem cell therapy in liver disease

Stuart J Forbes, Philip N Newsome

Research output: Contribution to journalArticlepeer-review


There is an increasing range of potential applications of stem cells in liver diseases, with many clinical studies already undertaken. We identify four of the main areas which we propose stem cell therapy could be a realistic aim for in the future: (1) to improve regeneration and reduce scarring in liver cirrhosis by modulating the liver's own regenerative processes, (2) to down-regulate immune mediated liver damage, (3) supplying hepatocyte-like cells (HLCs) derived from stem cells for use in extracorporeal bio-artificial liver machines, and (4) to use stem cell derived HLCs for cell transplantation to supplement or replace hepatocyte function.
Original languageEnglish
Pages (from-to)496-9
Number of pages4
JournalJournal of Hepatology
Issue number2
Publication statusPublished - Feb 2012


  • Liver Diseases
  • Hepatocytes
  • Humans
  • Liver Cirrhosis
  • Liver Regeneration
  • Stem Cell Transplantation

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