New insights into the aetiology of colorectal cancer from genome-wide association studies

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Genome-wide association studies have recently identified ten common genetic variants associated with colorectal cancer susceptibility, several suggesting the involvement of components of the transforming growth factor beta (TGFbeta) superfamily signalling pathway. To date, no causal sequence variants have been identified, and risk seems to be mediated through effects on gene regulation. Several markers are located close to poorly characterized genes or in gene deserts, raising challenges for elucidating mechanisms of susceptibility. Disease-associated common genetic variation offers the potential to refine risk stratification within populations and enable more targeted disease prevention strategies.
Original languageEnglish
Pages (from-to)353-8
Number of pages6
JournalNature Reviews Genetics
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2009

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