New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses

Conrad Schmoll; Ashraf Khan; Peter Aspinall; Colin Goudie; Peter Koay; Christelle Tendo; James Cameron; Jenny Roe; Ian Deary; Baljean Dhillon

doi:10.1136/bjophthalmol-2013-304024

New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses

Conrad Schmoll, Ashraf Khan, Peter Aspinall, Colin Goudie, Peter Koay, Christelle Tendo, James Cameron, Jenny Roe, Ian Deary, Baljean Dhillon

Research output: Contribution to journal › Article › peer-review

Abstract

Melanopsin-expressing photosensitive retinal ganglion cells form a blue-light-sensitive non-visual system mediating diverse physiological effects including circadian entrainment and cognitive alertness. Reduced blue wavelength retinal illumination through cataract formation is thought to blunt these responses while cataract surgery and intraocular lens (IOL) implantation have been shown to have beneficial effects on sleep and cognition. We aimed to use the reaction time (RT) task and the Epworth Sleepiness Score (ESS) as a validated objective platform to compare non-visual benefits of UV- and blue-blocking IOLs.

Original language	English
Pages (from-to)	124-128
Number of pages	5
Journal	British Journal of Ophthalmology
Volume	98
Issue number	1
DOIs	https://doi.org/10.1136/bjophthalmol-2013-304024
Publication status	Published - Jan 2014

Keywords / Materials (for Non-textual outputs)

Aged
Cataract
Circadian Rhythm
Cognition
Female
Humans
Lens Implantation, Intraocular
Lenses, Intraocular
Light
Male
Phacoemulsification
Prospective Studies
Questionnaires
Reaction Time
Regression Analysis
Rod Opsins
Sleep

Access to Document

10.1136/bjophthalmol-2013-304024

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I. (Principal Investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), McCulloch, J. (Co-investigator), Porteous, D. (Co-investigator), Roberts, N. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
1/09/08 → 31/08/13
Project: Research

Cite this

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title = "New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses",

abstract = "Melanopsin-expressing photosensitive retinal ganglion cells form a blue-light-sensitive non-visual system mediating diverse physiological effects including circadian entrainment and cognitive alertness. Reduced blue wavelength retinal illumination through cataract formation is thought to blunt these responses while cataract surgery and intraocular lens (IOL) implantation have been shown to have beneficial effects on sleep and cognition. We aimed to use the reaction time (RT) task and the Epworth Sleepiness Score (ESS) as a validated objective platform to compare non-visual benefits of UV- and blue-blocking IOLs.",

keywords = "Aged, Cataract, Circadian Rhythm, Cognition, Female, Humans, Lens Implantation, Intraocular, Lenses, Intraocular, Light, Male, Phacoemulsification, Prospective Studies, Questionnaires, Reaction Time, Regression Analysis, Rod Opsins, Sleep",

author = "Conrad Schmoll and Ashraf Khan and Peter Aspinall and Colin Goudie and Peter Koay and Christelle Tendo and James Cameron and Jenny Roe and Ian Deary and Baljean Dhillon",

year = "2014",

month = jan,

doi = "10.1136/bjophthalmol-2013-304024",

language = "English",

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AU - Schmoll, Conrad

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AU - Goudie, Colin

AU - Koay, Peter

AU - Tendo, Christelle

AU - Cameron, James

AU - Roe, Jenny

AU - Deary, Ian

AU - Dhillon, Baljean

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AB - Melanopsin-expressing photosensitive retinal ganglion cells form a blue-light-sensitive non-visual system mediating diverse physiological effects including circadian entrainment and cognitive alertness. Reduced blue wavelength retinal illumination through cataract formation is thought to blunt these responses while cataract surgery and intraocular lens (IOL) implantation have been shown to have beneficial effects on sleep and cognition. We aimed to use the reaction time (RT) task and the Epworth Sleepiness Score (ESS) as a validated objective platform to compare non-visual benefits of UV- and blue-blocking IOLs.

KW - Aged

KW - Cataract

KW - Circadian Rhythm

KW - Cognition

KW - Female

KW - Humans

KW - Lens Implantation, Intraocular

KW - Lenses, Intraocular

KW - Light

KW - Male

KW - Phacoemulsification

KW - Prospective Studies

KW - Questionnaires

KW - Reaction Time

KW - Regression Analysis

KW - Rod Opsins

KW - Sleep

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New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

MRC Centre for Cognitive Ageing and Cognitive Epidemiology

Cite this