Abstract / Description of output
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Original language | English |
---|---|
Pages (from-to) | 10495 |
Journal | Nature Communications |
Volume | 7 |
DOIs | |
Publication status | Published - 1 Feb 2016 |
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In: Nature Communications, Vol. 7, 01.02.2016, p. 10495.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
AU - Lu, Yingchang
AU - Day, Felix R
AU - Gustafsson, Stefan
AU - Buchkovich, Martin L
AU - Na, Jianbo
AU - Bataille, Veronique
AU - Cousminer, Diana L
AU - Dastani, Zari
AU - Drong, Alexander W
AU - Esko, Tõnu
AU - Evans, David M
AU - Falchi, Mario
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AU - Ferreira, Teresa
AU - Hedman, Åsa K
AU - Haring, Robin
AU - Hysi, Pirro G
AU - Iles, Mark M
AU - Justice, Anne E
AU - Kanoni, Stavroula
AU - Lagou, Vasiliki
AU - Li, Rui
AU - Li, Xin
AU - Locke, Adam
AU - Lu, Chen
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AU - Perry, John R B
AU - Pers, Tune H
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AU - Sanna, Marianna
AU - Schmidt, Ellen M
AU - Scott, William R
AU - Shungin, Dmitry
AU - Teumer, Alexander
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AU - Walker, Ryan W
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AU - Zhang, Mingfeng
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AU - Afzal, Uzma
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AU - Bakker, Stephan J L
AU - Bellis, Claire
AU - Bonnefond, Amélie
AU - Borodulin, Katja
AU - Buchman, Aron S
AU - Cederholm, Tommy
AU - Choh, Audrey C
AU - Choi, Hyung Jin
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AU - de Groot, Lisette C P G M
AU - De Jager, Philip L
AU - Dhonukshe-Rutten, Rosalie A M
AU - Enneman, Anke W
AU - Eury, Elodie
AU - Evans, Daniel S
AU - Forsen, Tom
AU - Friedrich, Nele
AU - Fumeron, Frédéric
AU - Garcia, Melissa E
AU - Gärtner, Simone
AU - Han, Bok-Ghee
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AU - Hayward, Caroline
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AU - Hillege, Hans
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AU - Kent, Jack W
AU - Kolcic, Ivana
AU - Laatikainen, Tiina
AU - Lahti, Jari
AU - Mateo Leach, Irene
AU - Lee, Christine G
AU - Lee, Jong-Young
AU - Liu, Tian
AU - Liu, Youfang
AU - Lobbens, Stéphane
AU - Loh, Marie
AU - Lyytikäinen, Leo-Pekka
AU - Medina-Gomez, Carolina
AU - Michaëlsson, Karl
AU - Nalls, Mike A
AU - Nielson, Carrie M
AU - Oozageer, Laticia
AU - Pascoe, Laura
AU - Paternoster, Lavinia
AU - Polašek, Ozren
AU - Ripatti, Samuli
AU - Sarzynski, Mark A
AU - Shin, Chan Soo
AU - Narančić, Nina Smolej
AU - Spira, Dominik
AU - Srikanth, Priya
AU - Steinhagen-Thiessen, Elisabeth
AU - Sung, Yun Ju
AU - Swart, Karin M A
AU - Taittonen, Leena
AU - Tanaka, Toshiko
AU - Tikkanen, Emmi
AU - van der Velde, Nathalie
AU - van Schoor, Natasja M
AU - Verweij, Niek
AU - Wright, Alan F
AU - Yu, Lei
AU - Zmuda, Joseph M
AU - Eklund, Niina
AU - Forrester, Terrence
AU - Grarup, Niels
AU - Jackson, Anne U
AU - Kristiansson, Kati
AU - Kuulasmaa, Teemu
AU - Kuusisto, Johanna
AU - Lichtner, Peter
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AU - Mahajan, Anubha
AU - Männistö, Satu
AU - Palmer, Cameron D
AU - Ried, Janina S
AU - Scott, Robert A
AU - Stancáková, Alena
AU - Wagner, Peter J
AU - Demirkan, Ayse
AU - Döring, Angela
AU - Gudnason, Vilmundur
AU - Kiel, Douglas P
AU - Kühnel, Brigitte
AU - Mangino, Massimo
AU - Mcknight, Barbara
AU - Menni, Cristina
AU - O'Connell, Jeffrey R
AU - Oostra, Ben A
AU - Shuldiner, Alan R
AU - Song, Kijoung
AU - Vandenput, Liesbeth
AU - van Duijn, Cornelia M
AU - Vollenweider, Peter
AU - White, Charles C
AU - Boehnke, Michael
AU - Boettcher, Yvonne
AU - Cooper, Richard S
AU - Forouhi, Nita G
AU - Gieger, Christian
AU - Grallert, Harald
AU - Hingorani, Aroon
AU - Jørgensen, Torben
AU - Jousilahti, Pekka
AU - Kivimaki, Mika
AU - Kumari, Meena
AU - Laakso, Markku
AU - Langenberg, Claudia
AU - Linneberg, Allan
AU - Luke, Amy
AU - Mckenzie, Colin A
AU - Palotie, Aarno
AU - Pedersen, Oluf
AU - Peters, Annette
AU - Strauch, Konstantin
AU - Tayo, Bamidele O
AU - Wareham, Nicholas J
AU - Bennett, David A
AU - Bertram, Lars
AU - Blangero, John
AU - Blüher, Matthias
AU - Bouchard, Claude
AU - Campbell, Harry
AU - Cho, Nam H
AU - Cummings, Steven R
AU - Czerwinski, Stefan A
AU - Demuth, Ilja
AU - Eckardt, Rahel
AU - Eriksson, Johan G
AU - Ferrucci, Luigi
AU - Franco, Oscar H
AU - Froguel, Philippe
AU - Gansevoort, Ron T
AU - Hansen, Torben
AU - Harris, Tamara B
AU - Hastie, Nicholas
AU - Heliövaara, Markku
AU - Hofman, Albert
AU - Jordan, Joanne M
AU - Jula, Antti
AU - Kähönen, Mika
AU - Kajantie, Eero
AU - Knekt, Paul B
AU - Koskinen, Seppo
AU - Kovacs, Peter
AU - Lehtimäki, Terho
AU - Lind, Lars
AU - Liu, Yongmei
AU - Orwoll, Eric S
AU - Osmond, Clive
AU - Perola, Markus
AU - Pérusse, Louis
AU - Raitakari, Olli T
AU - Rankinen, Tuomo
AU - Rao, D C
AU - Rice, Treva K
AU - Rivadeneira, Fernando
AU - Rudan, Igor
AU - Salomaa, Veikko
AU - Sørensen, Thorkild I A
AU - Stumvoll, Michael
AU - Tönjes, Anke
AU - Towne, Bradford
AU - Tranah, Gregory J
AU - Tremblay, Angelo
AU - Uitterlinden, André G
AU - van der Harst, Pim
AU - Vartiainen, Erkki
AU - Viikari, Jorma S
AU - Vitart, Veronique
AU - Vohl, Marie-Claude
AU - Völzke, Henry
AU - Walker, Mark
AU - Wallaschofski, Henri
AU - Wild, Sarah
AU - Wilson, James F
AU - Yengo, Loïc
AU - Bishop, D Timothy
AU - Borecki, Ingrid B
AU - Chambers, John C
AU - Cupples, L Adrienne
AU - Dehghan, Abbas
AU - Deloukas, Panos
AU - Fatemifar, Ghazaleh
AU - Fox, Caroline
AU - Furey, Terrence S
AU - Franke, Lude
AU - Han, Jiali
AU - Hunter, David J
AU - Karjalainen, Juha
AU - Karpe, Fredrik
AU - Kaplan, Robert C
AU - Kooner, Jaspal S
AU - McCarthy, Mark I
AU - Murabito, Joanne M
AU - Morris, Andrew P
AU - Bishop, Julia A N
AU - North, Kari E
AU - Ohlsson, Claes
AU - Ong, Ken K
AU - Prokopenko, Inga
AU - Richards, J Brent
AU - Schadt, Eric E
AU - Spector, Tim D
AU - Widén, Elisabeth
AU - Willer, Cristen J
AU - Yang, Jian
AU - Ingelsson, Erik
AU - Mohlke, Karen L
AU - Hirschhorn, Joel N
AU - Pospisilik, John Andrew
AU - Zillikens, M Carola
AU - Lindgren, Cecilia
AU - Kilpeläinen, Tuomas Oskari
AU - Loos, Ruth J F
PY - 2016/2/1
Y1 - 2016/2/1
N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
U2 - 10.1038/ncomms10495
DO - 10.1038/ncomms10495
M3 - Article
C2 - 26833246
SN - 2041-1723
VL - 7
SP - 10495
JO - Nature Communications
JF - Nature Communications
ER -