@article{b5f05d33473449c9a69e457a98ed4cba,
title = "New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases",
abstract = "The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potentially paving the way for a renaissance of neuroprotectants. Progress in basic science has been equally impressive. Based on a deeper understanding of pathomechanisms underlying cerebrovascular diseases, new therapeutic targets have been identified and novel treatment strategies such as pre- and post-conditioning methods were developed. Moreover, translationally relevant aspects are increasingly recognized in basic science studies, which is believed to increase their predictive value and the relevance of obtained findings for clinical application.This review reports key results from some of the most remarkable and encouraging achievements in neurovascular research that have been reported at the 10th International Symposium on Neuroprotection and Neurorepair. Basic science topics discussed herein focus on aspects such as neuroinflammation, extracellular vesicles, and the role of sex and age on stroke recovery. Translational reports highlighted endovascular techniques and targeted delivery methods, neurorehabilitation, advanced functional testing approaches for experimental studies, pre-and post-conditioning approaches as well as novel imaging and treatment strategies. Beyond ischemic stroke, particular emphasis was given on activities in the fields of traumatic brain injury and cerebral hemorrhage in which promising preclinical and clinical results have been reported. Although the number of neutral outcomes in clinical trials is still remarkably high when targeting cerebrovascular diseases, we begin to evidence stepwise but continuous progress towards novel treatment options. Advances in preclinical and translational research as reported herein are believed to have formed a solid foundation for this progress.",
keywords = "cell therapies, dementia, experimental therapy, hemorrhage, neuroprotection, neurorehabilitation, stroke, translational research",
author = "Johannes Boltze and Aronowski, {Jaroslaw A.} and Jerome Badaut and Buckwalter, {Marion S.} and Mateo Caleo and Michael Chopp and Dave, {Kunjan R.} and Nadine Didwischus and Dijkhuizen, {Rick M.} and Doeppner, {Thorsten R.} and Dreier, {Jens P.} and Karim Fouad and Mathias Gelderblom and Karen Gertz and Dominika Golubczyk and Gregson, {Barbara A.} and Edith Hamel and Hanley, {Daniel F.} and Wolfgang H{\"a}rtig and Hummel, {Friedhelm C.} and Maulana Ikhsan and Miroslaw Janowski and Jukka Jolkkonen and Karuppagounder, {Saravanan S.} and Keep, {Richard F.} and Koerte, {Inga K.} and Zaal Kokaia and Peiying Li and Fudong Liu and Ignacio Lizasoain and Peter Ludewig and Metz, {Gerlinde A.S.} and Axel Montagne and Andre Obenaus and Alex Palumbo and Monica Pearl and Miguel Perez-Pinzon and Planas, {Anna M.} and Nikolaus Plesnila and Raval, {Ami P.} and Rueger, {Maria A.} and Sansing, {Lauren H.} and Farida Sohrabji and Stagg, {Charlotte J.} and Stetler, {R. Anne} and Stowe, {Ann M.} and Dandan Sun and Akihiko Taguchi and Mickael Tanter and Vay, {Sabine U.} and Raghu Vemuganti and Denis Vivien and Piotr Walczak and Jian Wang and Ye Xiong and Marietta Zille",
note = "Funding Information: We wish to express our gratitude to all institutions and people who supported the 10th ISN&N. First and foremost, we want to thank all meeting participants for their outstanding academic contributions. Moreover, we are particularly grateful to the Deutsche Forschungsgemeinschaft (grant number: BO 3518/2-1) and the International Society of Cerebral Blood Flow and Metabolism, both of which supported the meeting with generous grants. We further acknowledge all industrial sponsors and exhibitors for their academic and invaluable financial support. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Boltze, Aronowski, Badaut, Buckwalter, Caleo, Chopp, Dave, Didwischus, Dijkhuizen, Doeppner, Dreier, Fouad, Gelderblom, Gertz, Golubczyk, Gregson, Hamel, Hanley, H{\"a}rtig, Hummel, Ikhsan, Janowski, Jolkkonen, Karuppagounder, Keep, Koerte, Kokaia, Li, Liu, Lizasoain, Ludewig, Metz, Montagne, Obenaus, Palumbo, Pearl, Perez-Pinzon, Planas, Plesnila, Raval, Rueger, Sansing, Sohrabji, Stagg, Stetler, Stowe, Sun, Taguchi, Tanter, Vay, Vemuganti, Vivien, Walczak, Wang, Xiong and Zille.",
year = "2021",
month = jan,
day = "28",
doi = "10.3389/fnagi.2021.623751",
language = "English",
volume = "13",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
}