@article{ec2b59c8cd984d5cb73752f3bb2d23e1,
title = "New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination",
abstract = "Oligodendrocytes that survive demyelination can remyelinate, including in multiple sclerosis (MS), but how they do so is unclear. In this study, using zebrafish, we found that surviving oligodendrocytes make few new sheaths and frequently mistarget new myelin to neuronal cell bodies, a pathology we also found in MS. In contrast, oligodendrocytes generated after demyelination make abundant and correctly targeted sheaths, indicating that they likely also have a better regenerative potential in MS.",
author = "Sarah Neely and Jill Williamson and Anna Klingseisen and Lida Zoupi and Jason Early and Williams, {Anna C} and Lyons, {David A}",
note = "Funding Information: We thank C. ffrench-Constant, E. Hughes and the Lyons Laboratory for feedback, the Bioresearch & Veterinary Services aquatics facility for fish care, S. Mitchell for electron microscopy assistance and C. Melendez-Vasquez for suggesting the ROCK experiment. This work was supported by Wellcome Trust Senior Research Fellowships (102836/Z/13/Z and 214244/Z/18/Z), a Medical Research Council Project Grant (MR/P006272/1) and an MS Society Innovative Grant (95) to D.A.L. S.A.N. and J.M.W. were supported by the Wellcome Trust Four-Year Ph.D. Program in Tissue Repair (grant 108906/Z/15/Z) and J.M.W. by a University of Edinburgh Ph.D. Tissue Repair Studentship Award (MRC Doctoral Training Partnership MR/K501293/1). L.Z. and A.W. were supported by an MS Society UK Centre grant. Funding Information: We thank C. ffrench-Constant, E. Hughes and the Lyons Laboratory for feedback, the Bioresearch & Veterinary Services aquatics facility for fish care, S. Mitchell for electron microscopy assistance and C. Melendez-Vasquez for suggesting the ROCK experiment. This work was supported by Wellcome Trust Senior Research Fellowships (102836/Z/13/Z and 214244/Z/18/Z), a Medical Research Council Project Grant (MR/P006272/1) and an MS Society Innovative Grant (95) to D.A.L. S.A.N. and J.M.W. were supported by the Wellcome Trust Four-Year Ph.D. Program in Tissue Repair (grant 108906/Z/15/Z) and J.M.W. by a University of Edinburgh Ph.D. Tissue Repair Studentship Award (MRC Doctoral Training Partnership MR/K501293/1). L.Z. and A.W. were supported by an MS Society UK Centre grant. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2022",
month = apr,
doi = "10.1038/s41593-021-01009-x",
language = "English",
volume = "25",
pages = "415--420",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "4",
}