New perspectives on rare connective tissue calcifying diseases

Nabil A Rashdan; Frank Rutsch; Hervé Kempf; András Váradi; Georges Lefthériotis; Vicky E Macrae

doi:10.1016/j.coph.2016.02.002

New perspectives on rare connective tissue calcifying diseases

Nabil A Rashdan, Frank Rutsch, Hervé Kempf, András Váradi, Georges Lefthériotis, Vicky E Macrae

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Connective tissue calcifying diseases (CTCs) are characterized by abnormal calcium deposition in connective tissues. CTCs are caused by multiple factors including chronic diseases (Type II diabetes mellitus, chronic kidney disease), the use of pharmaceuticals (e.g. warfarin, glucocorticoids) and inherited rare genetic diseases such as pseudoxanthoma elasticum (PXE), generalized arterial calcification in infancy (GACI) and Keutel syndrome (KTLS). This review explores our current knowledge of these rare inherited CTCs, and highlights the most promising avenues for pharmaceutical intervention. Advancing our understanding of rare inherited forms of CTC is not only essential for the development of therapeutic strategies for patients suffering from these diseases, but also fundamental to delineating the mechanisms underpinning acquired chronic forms of CTC.

Original language	English
Pages (from-to)	14-23
Journal	Current Opinion in Pharmacology
Volume	28
Early online date	27 Feb 2016
DOIs	https://doi.org/10.1016/j.coph.2016.02.002
Publication status	Published - 1 Jun 2016

Access to Document

10.1016/j.coph.2016.02.002

New perspectives on rare connective tissue calcifying diseases
2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons. org/licenses/by/4.0/).
Final published version, 1.22 MBLicence: Creative Commons: Attribution (CC-BY)

http://linkinghub.elsevier.com/retrieve/pii/S147148921630008X

Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

@article{4c61030fbb5c42499bad5431c16251ca,

title = "New perspectives on rare connective tissue calcifying diseases",

abstract = "Connective tissue calcifying diseases (CTCs) are characterized by abnormal calcium deposition in connective tissues. CTCs are caused by multiple factors including chronic diseases (Type II diabetes mellitus, chronic kidney disease), the use of pharmaceuticals (e.g. warfarin, glucocorticoids) and inherited rare genetic diseases such as pseudoxanthoma elasticum (PXE), generalized arterial calcification in infancy (GACI) and Keutel syndrome (KTLS). This review explores our current knowledge of these rare inherited CTCs, and highlights the most promising avenues for pharmaceutical intervention. Advancing our understanding of rare inherited forms of CTC is not only essential for the development of therapeutic strategies for patients suffering from these diseases, but also fundamental to delineating the mechanisms underpinning acquired chronic forms of CTC.",

author = "Rashdan, {Nabil A} and Frank Rutsch and Herv{\'e} Kempf and Andr{\'a}s V{\'a}radi and Georges Lefth{\'e}riotis and Macrae, {Vicky E}",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.coph.2016.02.002",

language = "English",

volume = "28",

pages = "14--23",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

publisher = "Elsevier",

}

TY - JOUR

T1 - New perspectives on rare connective tissue calcifying diseases

AU - Rashdan, Nabil A

AU - Rutsch, Frank

AU - Kempf, Hervé

AU - Váradi, András

AU - Lefthériotis, Georges

AU - Macrae, Vicky E

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Connective tissue calcifying diseases (CTCs) are characterized by abnormal calcium deposition in connective tissues. CTCs are caused by multiple factors including chronic diseases (Type II diabetes mellitus, chronic kidney disease), the use of pharmaceuticals (e.g. warfarin, glucocorticoids) and inherited rare genetic diseases such as pseudoxanthoma elasticum (PXE), generalized arterial calcification in infancy (GACI) and Keutel syndrome (KTLS). This review explores our current knowledge of these rare inherited CTCs, and highlights the most promising avenues for pharmaceutical intervention. Advancing our understanding of rare inherited forms of CTC is not only essential for the development of therapeutic strategies for patients suffering from these diseases, but also fundamental to delineating the mechanisms underpinning acquired chronic forms of CTC.

AB - Connective tissue calcifying diseases (CTCs) are characterized by abnormal calcium deposition in connective tissues. CTCs are caused by multiple factors including chronic diseases (Type II diabetes mellitus, chronic kidney disease), the use of pharmaceuticals (e.g. warfarin, glucocorticoids) and inherited rare genetic diseases such as pseudoxanthoma elasticum (PXE), generalized arterial calcification in infancy (GACI) and Keutel syndrome (KTLS). This review explores our current knowledge of these rare inherited CTCs, and highlights the most promising avenues for pharmaceutical intervention. Advancing our understanding of rare inherited forms of CTC is not only essential for the development of therapeutic strategies for patients suffering from these diseases, but also fundamental to delineating the mechanisms underpinning acquired chronic forms of CTC.

U2 - 10.1016/j.coph.2016.02.002

DO - 10.1016/j.coph.2016.02.002

M3 - Article

SN - 1471-4892

VL - 28

SP - 14

EP - 23

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

New perspectives on rare connective tissue calcifying diseases

Abstract

Access to Document

Fingerprint

Projects

Control of development and reproductive traits

Cite this