Projects per year
Understanding the rate and patterns of genome variation is becoming ever more amenable to whole-genome analysis through advances in DNA sequencing, which may, at least in some circumstances, have supplanted more localized analyses by cellular and genetic approaches. Whole-genome analyses can utilize both short- and long-read sequence technologies. Here we describe how sequence generated by these approaches has been used in trypanosomatids to examine DNA replication dynamics, the accumulation of modified histone H2A due to genome damage, and evaluation of genome variation, focusing on ploidy change.
|Title of host publication||Methods in Molecular Biology|
|Publisher||HUMANA PRESS INC|
|Number of pages||38|
|Publication status||E-pub ahead of print - 28 Mar 2020|
|Name||Methods in Molecular Biology|
- copy number variation
- DNA damage
- DNA replication
- next-generation sequencing
- single nucleotide polymorphisms
FingerprintDive into the research topics of 'Next-generation analysis of trypanosomatid genome stability and instability'. Together they form a unique fingerprint.
- 1 Active
Deciphering developmental commitment in African trypanosomes using single-cell transcriptomics
20/01/20 → 19/01/24