Abstract / Description of output
Phenotypic drug discovery (PDD) strategies are defined by screening and selection of hit or lead compounds based on quantifiable phenotypic endpoints without prior knowledge of the drug target. We outline the challenges associated with traditional phenotypic screening strategies and propose solutions and new opportunities to be gained by adopting modern PDD technologies. We highlight both historical and recent examples of approved drugs and new drug candidates discovered by modern phenotypic screening. Finally we offer a prospective view of a new era of PDD underpinned by a wealth of technology advances in the areas of in vitro model development, high content imaging and image-informatics, mechanism-of-action profiling and target deconvolution
| Original language | English |
|---|---|
| Journal | Future medicinal chemistry |
| Early online date | 30 Jun 2016 |
| DOIs | |
| Publication status | E-pub ahead of print - 30 Jun 2016 |
Keywords / Materials (for Non-textual outputs)
- Phenotypic
- Screening
- Target-deconvolution
- mechanism-of-action
- High-content
- image-informatics
- Transcriptomics
- Pathway profiling