Nitric oxide donors and the skin: useful therapectic agents?

R Weller*, Editorial Board, Richard Weller

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

Abstract

Nitric oxide (NO) is involved in several processes in the skin, including wound healing, pigmentation and regulation of apoptosis. Pharmacological intervention with NO donors appears to be a promising treatment for conditions such as diabetic ulceration. In this issue of Clinical Science, Khan et al. describe the synthesis of a number of NO donors, based on nitrosylated thiosugars, structural changes in which altered the rate of NO release. The in vivo behaviour of one of the donors was then measured by laser Doppler blood flow measurements on the skin. The ability to tailor the pharmacokinetic behaviour of these drugs should be of interest in developing NO donors for clinical use.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalClinical science
Volume105
Issue number5
DOIs
Publication statusPublished - Nov 2003

Keywords / Materials (for Non-textual outputs)

  • nitric oxide
  • S-nitrosated thiosugar
  • skin
  • vasodilatation
  • ACIDIFIED NITRITE
  • KERATINOCYTES
  • SYNTHASE
  • INVOLVEMENT
  • REPAIR
  • CREAM

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