No adverse hemodynamic interaction between sildenafil and red wine

Stephen J Leslie, Graham Atkins, James J Oliver, David J Webb

Research output: Contribution to journalArticlepeer-review

Abstract

Our objective was to investigate the hemodynamic interaction between sildenafil and red wine. Sildenafil citrate (Viagra), a phosphodiesterase type 5 inhibitor, is an effective treatment for male erectile dysfunction that potentiates nitric oxide-mediated vasodilation. Alcohol is a commonly used recreational substance with complex vascular effects, which may, in part, be mediated by nitric oxide. Thus there is potential for an adverse hemodynamic interaction.
Original languageEnglish
Pages (from-to)365-70
Number of pages6
JournalClinical pharmacology and therapeutics
Volume76
Issue number4
DOIs
Publication statusPublished - 2004

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