Nodal activity in the node governs left-right asymmetry

J Brennan, DP Norris, EJ Robertson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Nodal is expressed at the lateral edges of the mouse node, but its function in this "organizer" tissue remains unknown due to the early lethality of Nodal mutant embryos. Here we used a genetic strategy to selectively remove Nodal activity from the node. Embryos lacking Nodal in the node fail to initiate molecular asymmetry in the left lateral plate mesoderm and exhibit multiple left-right patterning defects. Nodal may also act as a short-range signal to establish a functional midline barrier. Out findings confirm that the mouse node is instrumental in initiating left-right axis specification and identify Nodal as the key morphogen regulating this process.

Original languageEnglish
Pages (from-to)2339-2344
Number of pages6
JournalGenes & Development
Volume16
Issue number18
DOIs
Publication statusPublished - 15 Sept 2002

Keywords / Materials (for Non-textual outputs)

  • Nodal
  • node
  • left-right asymmetry
  • isomerism
  • lateral plate mesoderm
  • mouse
  • LEFT-RIGHT AXIS
  • MOUSE EMBRYO
  • REGULATORY ELEMENTS
  • SITUS-INVERSUS
  • EXPRESSION
  • GENE
  • MORPHOGENESIS
  • PITX2
  • MICE
  • GASTRULATION

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