Projects per year
Abstract
This report presents a novel mechanism for remodelling a branched epithelial tree. The mouse renal collecting duct develops by growth and repeated branching of an initially unbranched ureteric bud: this mechanism initially produces an almost fractal form with young branches connected to the centre of the kidney via a sequence of nodes (branch points) distributed widely throughout the developing organ. The collecting ducts of a mature kidney have a different form: from the nephrons in the renal cortex, long, straight lengths of collecting duct run almost parallel to one another through the renal medulla, and open together to the renal pelvis. Here we present time-lapse studies of E11.5 kidneys growing in culture: after about 5 days, the collecting duct trees show evidence of 'node retraction', in which the node of a 'Y' shaped branch moves downwards, shortening the stalk of the 'Y', lengthening its arms and narrowing their divergence angle so that the 'Y' becomes a 'V'. Computer simulation suggests that node retraction can transform a spread tree, like that of an early kidney, into one with long, almost-parallel medullary rays similar to those seen in a mature real kidney.
Original language | English |
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Pages (from-to) | 13-21 |
Journal | Journal of Anatomy |
Volume | 226 |
Issue number | 1 |
Early online date | 8 Oct 2014 |
DOIs | |
Publication status | Published - Jan 2015 |
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Dive into the research topics of 'Node retraction during patterning of the urinary collecting duct system'. Together they form a unique fingerprint.Projects
- 4 Finished
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Project name: Functional testing of kidneys tissue-engineered from renogenic stem cells.
1/08/13 → 31/07/17
Project: Research
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Reducing mouse no complex genetic exper
Hohenstein, P.
UK central government bodies/local authorities, health and hospital authorities
1/10/12 → 9/07/14
Project: Research
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Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
1/04/12 → 31/03/17
Project: Research