Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis

Melpomeni K Tangalidi, Ioannis Oikonomidis, Dimitra Psalla, Serafim Papadimitriou, Maria Kritsepi-Konstantinou, Mathios E Mylonakis

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A 5.5-year-old, intact male Rottweiler dog was admitted with a history of multifocal nodular tongue lesions which progressively deteriorated during the previous year. Physical examination revealed several reddish nodules with central depression on the surface of the tongue in an otherwise healthy dog. Clinicopathologic abnormalities included eosinophilia and hyperproteinemia. Lingual nodule cytopathology, histopathology, and immunohistochemistry revealed Leishmania spp. amastigotes and a severe granulomatous glossitis. The dog was also seroreactive to L infantum antigens by an indirect immunofluorescence assay. Clinical reevaluation 3 months after the institution of treatment with allopurinol and miltefosine indicated that the nodular lesions had completely regressed. In endemic areas, lingual nodular lesions may rarely be the sole clinical sign of canine leishmaniosis. Standard medical treatment may provide an excellent prognosis.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalVeterinary Clinical Pathology: An International Journal of Laboratory Medicine
Issue number4
Early online date18 Oct 2016
Publication statusPublished - 15 Dec 2016

Keywords / Materials (for Non-textual outputs)

  • Allopurinol/therapeutic use
  • Animals
  • Antiprotozoal Agents/therapeutic use
  • Dog Diseases/diagnosis
  • Dogs
  • Drug Therapy, Combination
  • Fluorescent Antibody Technique, Indirect
  • Glossitis/diagnosis
  • Immunohistochemistry/veterinary
  • Leishmania infantum/immunology
  • Leishmaniasis, Visceral/diagnosis
  • Male
  • Phosphorylcholine/analogs & derivatives
  • Tongue/parasitology


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