Nodular hyperplasia of lymphoglandular complexes in dogs—a potential diagnostic pitfall for rectal masses

Andrew Stent*, Matti Kiupel, Julien Dandrieux, Rebekah Liffman, Monali M Bera

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Lymphoglandular complexes are components of the gut-associated lymphoid tissue that are characterized by submucosal lymphoid aggregates invested by projections of mucosal epithelium. Reports of pathology involving these structures are rare in both human and veterinary literature. Here we report two cases of rectal masses excised from dogs following a period of tenesmus and haematochezia. In both animals the masses were composed of lymphoid tissue closely encompassing tubuloacinar structures. Immunohistochemistry and PARR
testing demonstrated that the lymphoid population was polyclonal, comprising T and B cells arranged in loosely follicular aggregates centered on the epithelial foci. In light of these findings, a diagnosis of lymphoglandular complex nodular hyperplasia was reported. To the author’s knowledge, this is the first report of this condition in dogs.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalVeterinary Pathology
Early online date7 Aug 2023
DOIs
Publication statusE-pub ahead of print - 7 Aug 2023

Keywords / Materials (for Non-textual outputs)

  • Dog
  • Domestic Mammals
  • Species
  • Gastrointestinal
  • Digestive Tract
  • Tissue
  • Lymphoreticular
  • Immunohistochemistry
  • Technology
  • Hyperplasia
  • Histology
  • Lymphoglandular complex

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