Projects per year
Abstract / Description of output
Study question: Do the chemotherapeutic regimens of ABVD (adriamycin, bleomycin, vinblastine and dacarbazine), or OEPA-COPDAC (combined vincristine, etoposide, prednisone, doxorubicin (OEPA) and cyclophosphamide, vincristine, prednisone, dacarbazine (COPDAC)) used to treat Hodgkin lymphoma, affect the density, morphology and in vitro developmental potential of human ovarian follicles?
Summary answer: Ovarian tissue from women treated with ABVD contained a higher density of non-growing follicles/mm3 and increased numbers of multi-ovular follicles, but showed reduced in vitro growth compared with patients with lymphoma who had not received chemotherapy, patients treated with OEPA-COPDAC, age-matched healthy women and age-related model-predicted values.
Summary answer: Ovarian tissue from women treated with ABVD contained a higher density of non-growing follicles/mm3 and increased numbers of multi-ovular follicles, but showed reduced in vitro growth compared with patients with lymphoma who had not received chemotherapy, patients treated with OEPA-COPDAC, age-matched healthy women and age-related model-predicted values.
Original language | English |
---|---|
Journal | Human Reproduction |
Early online date | 5 Dec 2016 |
DOIs | |
Publication status | E-pub ahead of print - 5 Dec 2016 |
Keywords / Materials (for Non-textual outputs)
- OVARY
- follicle
- lymphoma
- ABVD
- oocyte
Fingerprint
Dive into the research topics of 'Non-growing follicle density is increased following adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy in the adult human ovary'. Together they form a unique fingerprint.Projects
- 2 Finished
-
Developmental and meiotic potential of oocytes derived from human ovarian germ line stem cells (OSCs) in vitro
1/11/13 → 28/05/16
Project: Research
-
Activation of human ovarian follicles and derivation of competent oocytes
1/07/10 → 30/10/13
Project: Research
Profiles
-
Evelyn Telfer
- School of Biological Sciences - Personal Chair in Reproductive Biology
Person: Academic: Research Active