Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants

Max Murray, Ivan Morrison

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of the immunostimulants Corynebacterium parvum, Bacillus Calmette-Guérin (BCG) or Bordetella pertussis prior to, or at the same time as, challenge with Trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged with Trypanosoma brucei following pre-treatment with C. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock.
Original languageEnglish
Pages (from-to)349-66
Number of pages18
JournalParasitology
Volume79
Issue number3
DOIs
Publication statusPublished - Dec 1979

Keywords

  • Animals
  • Antigens/immunology
  • Blood/parasitology
  • Bordetella pertussis/immunology
  • Corynebacterium/immunology
  • Immunity
  • Mice
  • Mice, Inbred Strains
  • Mycobacterium bovis/immunology
  • Trypanosoma/immunology
  • Trypanosoma brucei brucei/immunology
  • Trypanosomiasis, African/immunology

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