Noncoding RNAs: biology and applications—a Keystone Symposia report

Jennifer Cable*, Edith Heard, Tetsuro Hirose, Kannanganattu V. Prasanth, Ling Ling Chen, Jonathan E. Henninger, Sofia A. Quinodoz, David L. Spector, Sarah D. Diermeier, Allison M. Porman, Dhiraj Kumar, Mark W. Feinberg, Xiaohua Shen, Juan Pablo Unfried, Rory Johnson, Chun Kan Chen, Jeremy E. Wilusz, Adelheid Lempradl, Sean E. McGeary, Lamia WahbaAnna Marie Pyle, Amanda E. Hargrove, Matthew D. Simon, Marco Marcia, Róża K. Przanowska, Howard Y. Chang, Samie R. Jaffrey, Lydia M. Contreras, Junchao Shi, Joshua T. Mendell, Lin He, Erwei Song, John L. Rinn, Mukesh Kumar Lalwani, Murat Can Kalem, Edward B. Chuong, Lynne E. Maquat, Xuhang Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important roles in regulating transcription, epigenetic modifications, translation, and cell signaling. Roles for noncoding RNAs in disease mechanisms are also being uncovered, and several species have been identified as potential drug targets. On May 11–14, 2021, the Keystone eSymposium “Noncoding RNAs: Biology and Applications” brought together researchers working in RNA biology, structure, and technologies to accelerate both the understanding of RNA basic biology and the translation of those findings into clinical applications.

Original languageEnglish
Pages (from-to)118-141
Number of pages24
JournalAnnals of the New York Academy of Sciences
Issue number1
Early online date17 Nov 2021
Publication statusPublished - 20 Dec 2021


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