NONSENSE-MEDIATED MRNA DECAY IN CAENORHABDITIS ELEGANS

Dasa Longman; Pablo Arrisi; Iain L. Johnstone; Javier F. Caceres

doi:10.1016/S0076-68979(08)02407-5

NONSENSE-MEDIATED MRNA DECAY IN CAENORHABDITIS ELEGANS

Dasa Longman, Pablo Arrisi, Iain L. Johnstone, Javier F. Caceres

Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

Abstract / Description of output

The nonsense-mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs). Two key aspects of NMD are the definition of a PTC codon and the identification of the molecular machinery dedicated to this mechanism. This chapter describes the development of transgenic reporters as well as the use of genome-wide RNAi and genetic screens to identify novel components of the NMD pathway in the nematode Caenorhabditis elegans.

Original language	English
Title of host publication	RNA TURNOVER IN EUKARYOTES: ANALYSIS OF SPECIALIZED AND QUALITY CONTROL RNA DECAY PATHWAYS
Place of Publication	SAN DIEGO
Publisher	Academic Press
Pages	149-164
Number of pages	16
DOIs	https://doi.org/10.1016/S0076-68979(08)02407-5
Publication status	Published - 2008

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10.1016/S0076-68979(08)02407-5

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title = "NONSENSE-MEDIATED MRNA DECAY IN CAENORHABDITIS ELEGANS",

abstract = "The nonsense-mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs). Two key aspects of NMD are the definition of a PTC codon and the identification of the molecular machinery dedicated to this mechanism. This chapter describes the development of transgenic reporters as well as the use of genome-wide RNAi and genetic screens to identify novel components of the NMD pathway in the nematode Caenorhabditis elegans.",

author = "Dasa Longman and Pablo Arrisi and Johnstone, {Iain L.} and Caceres, {Javier F.}",

year = "2008",

doi = "10.1016/S0076-68979(08)02407-5",

language = "English",

pages = "149--164",

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T1 - NONSENSE-MEDIATED MRNA DECAY IN CAENORHABDITIS ELEGANS

AU - Longman, Dasa

AU - Arrisi, Pablo

AU - Johnstone, Iain L.

AU - Caceres, Javier F.

PY - 2008

Y1 - 2008

N2 - The nonsense-mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs). Two key aspects of NMD are the definition of a PTC codon and the identification of the molecular machinery dedicated to this mechanism. This chapter describes the development of transgenic reporters as well as the use of genome-wide RNAi and genetic screens to identify novel components of the NMD pathway in the nematode Caenorhabditis elegans.

AB - The nonsense-mediated mRNA decay (NMD) pathway is a surveillance mechanism that targets the degradation of mRNAs harboring premature termination codons (PTCs). Two key aspects of NMD are the definition of a PTC codon and the identification of the molecular machinery dedicated to this mechanism. This chapter describes the development of transgenic reporters as well as the use of genome-wide RNAi and genetic screens to identify novel components of the NMD pathway in the nematode Caenorhabditis elegans.

U2 - 10.1016/S0076-68979(08)02407-5

DO - 10.1016/S0076-68979(08)02407-5

M3 - Other chapter contribution

SP - 149

EP - 164

BT - RNA TURNOVER IN EUKARYOTES: ANALYSIS OF SPECIALIZED AND QUALITY CONTROL RNA DECAY PATHWAYS

PB - Academic Press

CY - SAN DIEGO

ER -

NONSENSE-MEDIATED MRNA DECAY IN CAENORHABDITIS ELEGANS

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