Not always the bad guys: B cells as regulators of autoimmune pathology

Simon Fillatreau; David Gray; Stephen M. Anderton

doi:10.1038/nri2315

Not always the bad guys: B cells as regulators of autoimmune pathology

Simon Fillatreau, David Gray, Stephen M. Anderton

Research output: Contribution to journal › Article › peer-review

Abstract

When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.

Original language	English
Pages (from-to)	391-397
Number of pages	7
Journal	Nature Reviews Immunology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1038/nri2315
Publication status	Published - May 2008

Access to Document

10.1038/nri2315

Cite this

@article{1e18f107c9684d8a9b52805460fa0810,

title = "Not always the bad guys: B cells as regulators of autoimmune pathology",

abstract = "When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.",

author = "Simon Fillatreau and David Gray and Anderton, {Stephen M.}",

year = "2008",

month = may,

doi = "10.1038/nri2315",

language = "English",

volume = "8",

pages = "391--397",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Not always the bad guys: B cells as regulators of autoimmune pathology

AU - Fillatreau, Simon

AU - Gray, David

AU - Anderton, Stephen M.

PY - 2008/5

Y1 - 2008/5

N2 - When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.

AB - When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.

U2 - 10.1038/nri2315

DO - 10.1038/nri2315

M3 - Article

VL - 8

SP - 391

EP - 397

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 5

ER -

Not always the bad guys: B cells as regulators of autoimmune pathology

Abstract

Access to Document

Fingerprint

Cite this