Not always the bad guys: B cells as regulators of autoimmune pathology

Simon Fillatreau, David Gray, Stephen M. Anderton

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

When B cells react aggressively against self, the potential for pathology is extreme. It is therefore not surprising that B-cell depletion is seen as an attractive therapy in autoimmune diseases. However, B cells can also be essential for restraining unwanted autoaggressive T-cell responses. Recent advances have pointed to interleukin-10 (IL-10) production as a key component in B-cell-mediated immune regulation. In this Opinion article, we develop a hypothesis that triggering of Toll-like receptors controls the propensity of B cells for IL-10 production and immune suppression. According to this model, B cells can translate exposure to certain microbial infections into protection from chronic inflammatory diseases.

Original languageEnglish
Pages (from-to)391-397
Number of pages7
JournalNature Reviews Immunology
Issue number5
Publication statusPublished - May 2008


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