Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation

Sarah Minnis-Lyons; Sofía Ferreira-Gonzalez; Niya Aleksieva; Janet Man; Victoria Gadd; Michael Williams; Rachel V Guest; Wei-Yu Lu; Benjamin Dwyer; Tam Jamieson; Colin NIxon; Noémi Van Hul; Frederic P. Lemaigre; John McCafferty; Isabelle Leclercq; O.J. Sansom; Luke Boulter; Stuart J Forbes

doi:10.1126/scisignal.aay9185

Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation

Sarah Minnis-Lyons, Sofía Ferreira-Gonzalez, Niya Aleksieva, Janet Man, Victoria Gadd, Michael Williams, Rachel V Guest, Wei-Yu Lu, Benjamin Dwyer, Tam Jamieson, Colin NIxon, Noémi Van Hul, Frederic P. Lemaigre, John McCafferty, Isabelle Leclercq, O.J. Sansom, Luke Boulter, Stuart J Forbes

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Science Signaling
DOIs	https://doi.org/10.1126/scisignal.aay9185
Publication status	Published - 22 Jun 2021

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10.1126/scisignal.aay9185Licence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

Minnis-Lyons et al Final_Manuscript_Submission_Final_2021_for_PureAccepted author manuscript, 2.51 MBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

1 Active
3 Finished

The molecular origin of ductular cancers in tubular morphogenesis
Boulter, L. (Principal Investigator)
UK-based charities
1/02/20 → 31/01/26
Project: Research
A forward genetics approach to define driver mutations in bile duct cancer
Boulter, L. (Principal Investigator)
UK-based charities
1/10/17 → 30/09/19
Project: Research
Autologous Macrophage Therapy for liver cirrhosis
Forbes, S. (Principal Investigator)
MRC
1/02/15 → 31/07/23
Project: Research

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Minnis-Lyons, S., Ferreira-Gonzalez, S., Aleksieva, N., Man, J., Gadd, V., Williams, M., Guest, R. V., Lu, W.-Y., Dwyer, B., Jamieson, T., NIxon, C., Van Hul, N., Lemaigre, F. P., McCafferty, J., Leclercq, I., Sansom, O. J., Boulter, L., & Forbes, S. J. (2021). Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation. Science Signaling. https://doi.org/10.1126/scisignal.aay9185

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title = "Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation",

author = "Sarah Minnis-Lyons and Sof{\'i}a Ferreira-Gonzalez and Niya Aleksieva and Janet Man and Victoria Gadd and Michael Williams and Guest, {Rachel V} and Wei-Yu Lu and Benjamin Dwyer and Tam Jamieson and Colin NIxon and {Van Hul}, No{\'e}mi and Lemaigre, {Frederic P.} and John McCafferty and Isabelle Leclercq and O.J. Sansom and Luke Boulter and Forbes, {Stuart J}",

year = "2021",

month = jun,

day = "22",

doi = "10.1126/scisignal.aay9185",

language = "English",

journal = "Science Signaling",

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Minnis-Lyons, S, Ferreira-Gonzalez, S, Aleksieva, N, Man, J , Gadd, V, Williams, M, Guest, RV , Lu, W-Y, Dwyer, B, Jamieson, T, NIxon, C, Van Hul, N, Lemaigre, FP, McCafferty, J, Leclercq, I, Sansom, OJ, Boulter, L & Forbes, SJ 2021, 'Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation', Science Signaling. https://doi.org/10.1126/scisignal.aay9185

TY - JOUR

T1 - Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation

AU - Minnis-Lyons, Sarah

AU - Ferreira-Gonzalez, Sofía

AU - Aleksieva, Niya

AU - Man, Janet

AU - Gadd, Victoria

AU - Williams, Michael

AU - Guest, Rachel V

AU - Lu, Wei-Yu

AU - Dwyer, Benjamin

AU - Jamieson, Tam

AU - NIxon, Colin

AU - Van Hul, Noémi

AU - Lemaigre, Frederic P.

AU - McCafferty, John

AU - Leclercq, Isabelle

AU - Sansom, O.J.

AU - Boulter, Luke

AU - Forbes, Stuart J

PY - 2021/6/22

Y1 - 2021/6/22

U2 - 10.1126/scisignal.aay9185

DO - 10.1126/scisignal.aay9185

M3 - Article

SN - 1945-0877

JO - Science Signaling

JF - Science Signaling

ER -

Notch-IGF1 signalling in biliary epithelial cells drives their expansion and inhibits hepatocyte differentiation

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Projects

The molecular origin of ductular cancers in tubular morphogenesis

A forward genetics approach to define driver mutations in bile duct cancer

Autologous Macrophage Therapy for liver cirrhosis

Cite this